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Mitogen Activated Protein Kinase Kinase 6 (MAP2K6)

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MEK6; MKK6; PRKMK6; SAPKK3; SKK3; Stress-activated protein kinase kinase 3

Mitogen Activated Protein Kinase Kinase 6 (MAP2K6)
CCC B721
HGNC 6846
MGI 1346870
PubMed 22383536
RGD 620666
UniProt P52564
Wiki MAP2K6

Mitogen-activated protein kinase kinase 6, is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals.

This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB721Hu01 Recombinant Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB721Hu01 Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) ELISA Kit Customized Service Offer
  1. "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway."Mol. Cell. Biol. 16:1247-1255(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade."J. Biol. Chem. 271:11427-11433(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the structure and function of a novel MAP kinase kinase (MKK6)."J. Biol. Chem. 271:2886-2891(1996) [PubMed] [Europe PMC] [Abstract]
  4. "A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3."J. Biol. Chem. 271:13675-13679(1996) [PubMed] [Europe PMC] [Abstract]
  5. "Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells."EMBO J. 15:4156-4164(1996) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases."EMBO J. 16:3563-3571(1997) [PubMed] [Europe PMC] [Abstract]
  8. "Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2."Curr. Biol. 8:1049-1057(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades."Biochem. J. 336:599-609(1998) [PubMed] [Europe PMC] [Abstract]
  10. "MEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases."J. Biol. Chem. 274:16604-16610(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain."J. Biol. Chem. 274:28803-28807(1999) [PubMed] [Europe PMC] [Abstract]
  12. "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."Nature 398:252-256(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor."Biochem. J. 352:739-745(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity."Blood 96:1844-1852(2000) [PubMed] [Europe PMC] [Abstract]
  15. "The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription."Biol. Chem. 382:1447-1453(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress."EMBO J. 20:6028-6036(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2."J. Biol. Chem. 276:16070-16075(2001) [PubMed] [Europe PMC] [Abstract]
  18. "TAK1 is a ubiquitin-dependent kinase of MKK and IKK."Nature 412:346-351(2001) [PubMed] [Europe PMC] [Abstract]
  19. "Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation."J. Biol. Chem. 279:37670-37676(2004) [PubMed] [Europe PMC] [Abstract]
  20. "p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs."J. Biol. Chem. 279:45308-45311(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase."J. Biol. Chem. 280:3323-3330(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases."Mol. Cell 18:295-306(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation."Science 312:1211-1214(2006) [PubMed] [Europe PMC] [Abstract]
  24. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation."Biochemistry 49:4094-4102(2010) [PubMed] [Europe PMC] [Abstract]
  26. "MKK6 increases the melanocyte dendricity through the regulation of Rho family GTPases."J. Dermatol. Sci. 60:114-119(2010) [PubMed] [Europe PMC] [Abstract]
  27. "Signaling by dual specificity kinases."Oncogene 17:1447-1455(1998) [PubMed] [Europe PMC] [Abstract]
  28. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  29. "The structure of the MAP2K MEK6 reveals an autoinhibitory dimer."Structure 17:96-104(2009) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of human mitogen-activated protein kinase kinase 6 (mek6) activated mutant (s207d, t211d)."Submitted (JUL-2011) to the PDB data bank