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Glycophorin C (GYPC)

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CD236; CD236R; GYP-C; PAS-2; GPC; GYPD; Ge; Glycoprotein Beta; Glycoconnectin; Gerbich Blood Group; Glycophorin-D; Sialoglycoprotein D

Glycophorin C (GYPC)
CCC B711
HGNC 4704
MGI 1098566
PubMed 11719395
UniProt P04921
Wiki Glycophorin_C

Glycophorin C (GPC) is a single polypeptide chain of 128 amino acids and is encoded by a gene on the long arm of Chromosome 2 (2q14-q21). Two isoforms are known and the gene is expressed in a wide variety of tissues including kidney, thymus, stomach, breast, adult liver and erythrocyte. In the non erythroid cell lines, expression is lower than in the erythrocyte and the protein is differentially glycosylated. In the erythrocyte glycophorin C makes up ~4% of the membrane sialoglycoproteins.
The GPC gene is organized in four exons distributed over 13.5 kilobase pairs of DNA and contains two directly repeated domains 3.4 kilobase pairs long which may be derived from a recent duplication of a single ancestral domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB711Hu01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB711Hu01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glycophorin C (GYPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycophorin C (GYPC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB711Mu01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB711Mu01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glycophorin C (GYPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycophorin C (GYPC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB711Ra01 Recombinant Glycophorin C (GYPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB711Ra01 Polyclonal Antibody to Glycophorin C (GYPC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glycophorin C (GYPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glycophorin C (GYPC) ELISA Kit Customized Service Offer
  1. "Isolation of cDNA clones and complete amino acid sequence of human erythrocyte glycophorin C."J. Biol. Chem. 261:229-233(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Human erythrocyte membrane sialoglycoprotein beta. The cDNA sequence suggests the absence of a cleaved N-terminal signal sequence."Biochem. J. 243:277-280(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Structure of human erythrocyte glycophorin C deduced from cDNA analysis."Rev. Fr. Transfus. Immunohematol. 29:267-285(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Gerbich blood group deficiency of the Ge:-1,-2,-3 and Ge:-1,-2,3 types. Immunochemical study and genomic analysis with cDNA probes."Eur. J. Biochem. 165:571-579(1987) [PubMed] [Europe PMC] [Abstract]
  5. "An ubiquitous isoform of glycophorin C is produced by alternative splicing."Nucleic Acids Res. 18:3076-3076(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Glycophorins B and C from human erythrocyte membranes. Purification and sequence analysis."J. Biol. Chem. 262:5808-5811(1987) [PubMed] [Europe PMC] [Abstract]
  10. "Isolation and structural analysis of glycophorin C."Biol. Chem. Hoppe-Seyler 366:777-778(1985)
  11. "A revision of the N-terminal structure of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes."Biol. Chem. Hoppe-Seyler 366:1067-1070(1985) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal amino acid sequence of sialoglycoprotein D (glycophorin C) from human erythrocyte membranes."Eur. J. Biochem. 125:57-62(1982) [PubMed] [Europe PMC] [Abstract]
  13. "Structural homology between glycophorins C and D of human erythrocytes."Eur. J. Biochem. 183:639-643(1989) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of the promoter region and tissue specificity of the human glycophorin C gene."J. Biol. Chem. 264:20407-20414(1989) [PubMed] [Europe PMC] [Abstract]
  15. "Rearrangements of the red-cell membrane glycophorin C (sialoglycoprotein beta) gene. A further study of alterations in the glycophorin C gene."Biochem. J. 262:47-54(1989) [PubMed] [Europe PMC] [Abstract]
  16. "Human erythrocyte glycophorin C. Gene structure and rearrangement in genetic variants."J. Biol. Chem. 264:3773-3780(1989) [PubMed] [Europe PMC] [Abstract]
  17. "Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations."Nat. Med. 9:87-92(2003) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Molecular characterization of erythrocyte glycophorin C variants."Blood 77:644-648(1991) [PubMed] [Europe PMC] [Abstract]
  22. "Point mutation in the glycophorin C gene results in the expression of the blood group antigen Dha."Vox Sang. 63:56-58(1992) [PubMed] [Europe PMC] [Abstract]
  23. "A point mutation in the GYPC gene results in the expression of the blood group Ana antigen on glycophorin D but not on glycophorin C: further evidence that glycophorin D is a product of the GYPC gene."Blood 82:3198-3203(1993) [PubMed] [Europe PMC] [Abstract]