Trefoil Factor 3 (TFF3)

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HITF; ITF3; TFI; HP1.B; Trefoil Factor 3, Intestinal

Trefoil Factor 3 (TFF3)

Trefoil factor 3 is a protein encoded by the TFF3 gene. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB656Hu01 Recombinant Trefoil Factor 3 (TFF3) Positive Control; Immunogen; SDS-PAGE; WB.
APB656Hu01 Active Trefoil Factor 3 (TFF3) Cell culture; Activity Assays.
Antibodies PAB656Hu01 Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; ICC; IHC-P; IHC-F; ELISA.
MAB656Hu22 Monoclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC; IP.
LAB656Hu71 Biotin-Linked Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC.
Assay Kits SEB656Hu ELISA Kit for Trefoil Factor 3 (TFF3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB656Hu CLIA Kit for Trefoil Factor 3 (TFF3) Chemiluminescent immunoassay for Antigen Detection.
HEB656Hu High Sensitive ELISA Kit for Trefoil Factor 3 (TFF3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB656Mu01 Recombinant Trefoil Factor 3 (TFF3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB656Mu02 Recombinant Trefoil Factor 3 (TFF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB656Mu01 Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC; IP.
LAB656Mu71 Biotin-Linked Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC.
PAB656Mu02 Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC; IP.
Assay Kits SEB656Mu ELISA Kit for Trefoil Factor 3 (TFF3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB656Ra01 Recombinant Trefoil Factor 3 (TFF3) Positive Control; Immunogen; SDS-PAGE; WB.
CPB656Ra21 OVA Conjugated Trefoil Factor 3 (TFF3) Immunogen; SDS-PAGE; WB.
Antibodies PAB656Ra01 Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC; IP.
LAB656Ra71 Biotin-Linked Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC.
MAB656Ra21 Monoclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC; IP.
PAB656Ra08 Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC; IP.
Assay Kits SEB656Ra ELISA Kit for Trefoil Factor 3 (TFF3) Enzyme-linked immunosorbent assay for Antigen Detection.
HEB656Ra High Sensitive ELISA Kit for Trefoil Factor 3 (TFF3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB656Ca01 Recombinant Trefoil Factor 3 (TFF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB656Ca01 Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC; IP.
LAB656Ca71 Biotin-Linked Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Trefoil Factor 3 (TFF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trefoil Factor 3 (TFF3) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB656Po01 Recombinant Trefoil Factor 3 (TFF3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB656Po02 Recombinant Trefoil Factor 3 (TFF3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB656Po03 Recombinant Trefoil Factor 3 (TFF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB656Po01 Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC; IP.
LAB656Po71 Biotin-Linked Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC.
PAB656Po02 Polyclonal Antibody to Trefoil Factor 3 (TFF3) WB; IHC; ICC; IP.
PAB656Po03 Polyclonal Antibody to Trefoil Factor 3 (TFF3) Applications: WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Trefoil Factor 3 (TFF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Trefoil Factor 3 (TFF3) ELISA Kit Customized Service Offer
  1. "hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus."Proc. Natl. Acad. Sci. U.S.A. 90:6961-6965(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3."Genomics 40:200-202(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region."Genomics 68:22-29(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "mRNA 5' region sequence incompleteness: a potential source of systematic errors in translation initiation codon assignment in human mRNAs."Gene 321:185-193(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion."J. Biol. Chem. 268:6694-6702(1993) [PubMed] [Europe PMC] [Abstract]
  8. ErratumJ. Biol. Chem. 268:12230-12230(1993)
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Comprehensive proteomic analysis of human endometrial fluid aspirate."J. Proteome Res. 8:4622-4632(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Coexistence of intestinal trefoil factor (hITF) and oxytocin in magnocellular neurons in the human hypothalamus."Horm. Metab. Res. 32:121-124(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Trefoil factor family-peptides promote migration of human bronchial epithelial cells: synergistic effect with epidermal growth factor."Am. J. Respir. Cell Mol. Biol. 25:418-424(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Incorporation of mannose and glucose into prenylphosphate sugars in isolated human platelet membranes."Biochim. Biophys. Acta 498:341-348(1977) [PubMed] [Europe PMC] [Abstract]
  14. "Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins."Biochemistry 42:15139-15147(2003) [PubMed] [Europe PMC] [Abstract]