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Cytosolic Phospholipase A2 (PLA2G4)

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c-PLA2; cPLA2; PLA2G4A; Phospholipase A2, Cytosolic; Phospholipase A2,Group IV(Cytosolic,Calcium-Dependent); Phosphatidylcholine 2-acylhydrolase; Lysophospholipase

Cytosolic Phospholipase A2 (PLA2G4)
CCC B624
HGNC 9035
MGI 1195256
PubMed 8910365
RGD 67366
UniProt P47712
Wiki PLA2G4A

  • Cytosolic phospholipases A2 (cPLA2): The intracellular PLA2 are also Ca-dependent, but they have completely different 3D structure and significantly larger than secreted PLA2 (more than 700 residues). They include C2 domain and large catalytic domain. These phospholipases are involved in cell signaling processes, such as inflammatory response. The produced Arachidonic acid is both a signaling molecule and the precursor for other signalling molecules termed eicosanoids. These include leukotrienes and prostaglandins. Some eicosanoids are synthesized from diacylglycerol, released from the lipid bilayer by phospholipase C (see below). Phospholipases A2 can be classified based on sequence homology.PLA2G4A, the cytosolic phospholipase A2, appears to subserve transmembrane signaling responses to extracellular ligands

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB624Hu01 Recombinant Cytosolic Phospholipase A2 (PLA2G4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB624Hu02 Recombinant Cytosolic Phospholipase A2 (PLA2G4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB624Hu02 Polyclonal Antibody to Cytosolic Phospholipase A2 (PLA2G4) WB; IHC; ICC; IP.
PAB624Hu01 Polyclonal Antibody to Cytosolic Phospholipase A2 (PLA2G4) WB; IHC; ICC; IP.
LAB624Hu71 Biotin-Linked Polyclonal Antibody to Cytosolic Phospholipase A2 (PLA2G4) WB; IHC; ICC.
MAB624Hu21 Monoclonal Antibody to Cytosolic Phospholipase A2 (PLA2G4) WB,IHC
MAB624Hu22 Monoclonal Antibody to Cytosolic Phospholipase A2 (PLA2G4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cytosolic Phospholipase A2 (PLA2G4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytosolic Phospholipase A2 (PLA2G4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB624Mu01 Recombinant Cytosolic Phospholipase A2 (PLA2G4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB624Mu01 Polyclonal Antibody to Cytosolic Phospholipase A2 (PLA2G4) WB; IHC; ICC; IP.
Assay Kits SEB624Mu ELISA Kit for Cytosolic Phospholipase A2 (PLA2G4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytosolic Phospholipase A2 (PLA2G4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytosolic Phospholipase A2 (PLA2G4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytosolic Phospholipase A2 (PLA2G4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytosolic Phospholipase A2 (PLA2G4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytosolic Phospholipase A2 (PLA2G4) ELISA Kit Customized Service Offer
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  10. "PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production."Mol. Cell. Biol. 21:4470-4481(2001) [PubMed] [Europe PMC] [Abstract]
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  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction."J. Clin. Invest. 118:2121-2131(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2."J. Biol. Chem. 273:1596-1604(1998) [PubMed] [Europe PMC] [Abstract]
  20. "Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2."J. Mol. Biol. 280:485-500(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism."Cell 97:349-360(1999) [PubMed] [Europe PMC] [Abstract]
  22. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]