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Surfactant Protein B (SP-B)

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SFTPB; PSPB; SFTB3; SFTP3; SPB; Surfactant Associated Protein B; Pulmonary Surfactant Protein B; 18 kDa pulmonary-surfactant protein; 6 kDa protein

Surfactant Protein B (SP-B)
CCC B622
HGNC 10801
MGI 109516
PubMed 8460718
RGD 621700
UniProt P07988
Wiki SPB

SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. Pulmonary surfactant-associated protein B' is a membrane protein which manufactures surfactant.Humans and animals born with a congenital absence of SP-B suffer from intractable respiratory failure.

The SFTPB is an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a lipid-rich material that prevents lung collapse by lowering surface tension at the air-liquid interface in the alveoli of lung. SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB622Hu01 Recombinant Surfactant Protein B (SP-B) Positive Control; Immunogen; SDS-PAGE; WB.
RPB622Hu02 Recombinant Surfactant Protein B (SP-B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB622Hu01 Polyclonal Antibody to Surfactant Protein B (SP-B) WB; IHC; ICC; IP.
MAB622Hu22 Monoclonal Antibody to Surfactant Protein B (SP-B) WB; IHC; ICC; IP.
Assay Kits SEB622Hu ELISA Kit for Surfactant Protein B (SP-B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB622Mu01 Recombinant Surfactant Protein B (SP-B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB622Mu01 Polyclonal Antibody to Surfactant Protein B (SP-B) WB; IHC; ICC; IP.
LAB622Mu71 Biotin-Linked Polyclonal Antibody to Surfactant Protein B (SP-B) WB; IHC; ICC.
Assay Kits SEB622Mu ELISA Kit for Surfactant Protein B (SP-B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB622Ra01 Recombinant Surfactant Protein B (SP-B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB622Ra01 Polyclonal Antibody to Surfactant Protein B (SP-B) WB; IHC; ICC; IP.
MAB622Ra21 Monoclonal Antibody to Surfactant Protein B (SP-B) WB; IHC; ICC; IP.
Assay Kits SEB622Ra ELISA Kit for Surfactant Protein B (SP-B) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein."J. Biol. Chem. 262:9808-9811(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B."DNA 8:75-86(1989) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe)."Proc. Natl. Acad. Sci. U.S.A. 84:4007-4011(1987) [PubMed] [Europe PMC] [Abstract]
  5. "Use of human surfactant low molecular weight apoproteins in the reconstitution of surfactant biologic activity."J. Clin. Invest. 81:826-833(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Human surfactant polypeptide SP-B. Disulfide bridges, C-terminal end, and peptide analysis of the airway form."FEBS Lett. 301:165-167(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Conformational mapping of the N-terminal segment of surfactant protein B in lipid using 13C-enhanced Fourier transform infrared spectroscopy."J. Pept. Res. 55:330-347(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles."Biochemistry 46:11047-11056(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Partial deficiency of surfactant protein B in an infant with chronic lung disease."Pediatrics 96:1046-1052(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS."Clin. Genet. 58:181-191(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome."Hum. Mol. Genet. 9:2751-2760(2000) [PubMed] [Europe PMC] [Abstract]