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Cluster Of Differentiation 209 (CD209)

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CLEC4L; DC-SIGN; CDSIGN; C-Type Lectin Domain Family 4, Member L; Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Non-Integrin

Cluster Of Differentiation 209 (CD209)
CCC B614
HGNC 1641
MGI 2157942
PubMed 12477827
RGD 1308239
UniProt Q9NNX6
Wiki DC-SIGN

DC-SIGN is a C-type lectin receptor present on both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds to mannose type carbohydrates, a class of Pathogen associated molecular patterns PAMPs commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis. On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4 T cells, as well as recognition of pathogen haptens.DC-SIGN is a C-type lectin and has a high affinity for the ICAM3 molecule. It binds various microorganisms by recognizing high-mannose-containing glycoproteins on their envelopes and especially functions as receptor for several viruses such as HIV and Hepatitis C.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB614Hu01 Recombinant Cluster Of Differentiation 209 (CD209) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB614Hu01 Polyclonal Antibody to Cluster Of Differentiation 209 (CD209) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 209 (CD209) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 209 (CD209) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB614Mu01 Recombinant Cluster Of Differentiation 209 (CD209) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB614Mu01 Polyclonal Antibody to Cluster Of Differentiation 209 (CD209) WB; IHC
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 209 (CD209) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 209 (CD209) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster Of Differentiation 209 (CD209) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster Of Differentiation 209 (CD209) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster Of Differentiation 209 (CD209) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 209 (CD209) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 209 (CD209) ELISA Kit Customized Service Offer
  1. "Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp 120."Proc. Natl. Acad. Sci. U.S.A. 89:8356-8360(1992) [PubMed] [Europe PMC] [Abstract]
  2. "DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13."J. Immunol. 165:2937-2942(2000) [PubMed] [Europe PMC] [Abstract]
  3. "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection."J. Exp. Med. 193:671-678(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts."J. Biol. Chem. 276:33196-33212(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells."Cell 100:587-597(2000) [PubMed] [Europe PMC] [Abstract]
  9. "DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking."Nat. Immunol. 1:353-357(2000) [PubMed] [Europe PMC] [Abstract]
  10. "A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands."J. Biol. Chem. 276:28939-28945(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection."Immunity 17:653-664(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1."J. Biol. Chem. 277:11314-11320(2002) [PubMed] [Europe PMC] [Abstract]
  13. "The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells."J. Immunol. 168:2118-2126(2002) [PubMed] [Europe PMC] [Abstract]
  14. "DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection."Immunity 16:135-144(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR."J. Virol. 77:1337-1346(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Inhibition of human immunodeficiency virus type 1 Env-mediated fusion by DC-SIGN."J. Virol. 77:5313-5323(2003) [PubMed] [Europe PMC] [Abstract]
  17. "Carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells."J. Immunol. 170:1635-1639(2003) [PubMed] [Europe PMC] [Abstract]
  18. "DC-SIGN: escape mechanism for pathogens."Nat. Rev. Immunol. 3:697-709(2003) [PubMed] [Europe PMC] [Abstract]
  19. "The role of dendritic cell C-type lectin receptors in HIV pathogenesis."J. Leukoc. Biol. 74:710-718(2003) [PubMed] [Europe PMC] [Abstract]
  20. "L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus."Proc. Natl. Acad. Sci. U.S.A. 101:14067-14072(2004) [PubMed] [Europe PMC] [Abstract]
  21. "A variant in the CD209 promoter is associated with severity of dengue disease." Nat. Genet. 37:507-513(2005) [PubMed] [Europe PMC] [Abstract]
  22. "DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells."Blood 120:1228-1236(2012) [PubMed] [Europe PMC] [Abstract]
  23. "Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR."Science 294:2163-2166(2001) [PubMed] [Europe PMC] [Abstract]
  24. "Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis."PLoS Med. 3:230-235(2006) [PubMed] [Europe PMC] [Abstract]