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Chorionic Gonadotropin Alpha Polypeptide (CGa)

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FSHA; GPHA1; GPHa; HCG; LHA; TSHA; Thyroid Stimulating Hormone Alpha; Follicle-Stimulating Hormone Alpha Subunit; Luteinizing hormone alpha chain; Lutropin alpha chain

Chorionic Gonadotropin Alpha Polypeptide (CGa)
CCC B612
HGNC 1885
MGI 88390
PubMed 3465528
RGD 620436
UniProt P01215
Wiki CGA

Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced in pregnancy that is made by the developing embryo soon after conception and later by the syncytiotrophoblast (part of the placenta).

Its role is to prevent the disintegration of the corpus luteum of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans. hCG may have additional functions; for instance, it is thought that hCG affects the immune tolerance of the pregnancy. Early pregnancy testing, in general, is based on the detection or measurement of hCG. Because hCG is produced also by some kinds of tumor, hCG is an important tumor marker, but it is not known whether this production is a contributing cause or an effect of tumorigenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB612Hu01 Recombinant Chorionic Gonadotropin Alpha Polypeptide (CGa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB612Hu01 Polyclonal Antibody to Chorionic Gonadotropin Alpha Polypeptide (CGa) WB; IHC; ICC; IP.
MAB612Hu22 Monoclonal Antibody to Chorionic Gonadotropin Alpha Polypeptide (CGa) WB.
LAB612Hu71 Biotin-Linked Polyclonal Antibody to Chorionic Gonadotropin Alpha Polypeptide (CGa) WB; IHC; ICC.
MAB612Hu21 Monoclonal Antibody to Chorionic Gonadotropin Alpha Polypeptide (CGa) WB
Assay Kits CEB612Hu ELISA Kit for Chorionic Gonadotropin Alpha Polypeptide (CGa) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB612Hu ELISA Kit for Chorionic Gonadotropin Alpha Polypeptide (CGa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB612Mu01 Recombinant Chorionic Gonadotropin Alpha Polypeptide (CGa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB612Mu01 Polyclonal Antibody to Chorionic Gonadotropin Alpha Polypeptide (CGa) WB,IHC
LAB612Mu71 Biotin-Linked Polyclonal Antibody to Chorionic Gonadotropin Alpha Polypeptide (CGa) WB; IHC; ICC.
LAB612Mu81 FITC-Linked Polyclonal Antibody to Chorionic Gonadotropin Alpha Polypeptide (CGa) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Chorionic Gonadotropin Alpha Polypeptide (CGa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chorionic Gonadotropin Alpha Polypeptide (CGa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chorionic Gonadotropin Alpha Polypeptide (CGa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chorionic Gonadotropin Alpha Polypeptide (CGa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chorionic Gonadotropin Alpha Polypeptide (CGa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chorionic Gonadotropin Alpha Polypeptide (CGa) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chorionic Gonadotropin Alpha Polypeptide (CGa) ELISA Kit Customized Service Offer
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  2. "Structure and regulation of human thyroid-stimulating hormone (TSH) gene."Nippon Rinsho 52:940-947(1994) [PubMed] [Europe PMC] [Abstract]
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  5. "The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin."J. Biol. Chem. 256:1816-1823(1981) [PubMed] [Europe PMC] [Abstract]
  6. "Human pituitary thyrotropin. The primary structure of the alpha and beta subunits."Can. J. Biochem. 55:755-760(1977) [PubMed] [Europe PMC] [Abstract]
  7. "Human pituitary interstitial cell stimulating hormone: primary structure of the alpha-subunit."Biochem. Biophys. Res. Commun. 48:530-537(1972) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of human luteninizing hormone."Fed. Proc. 37:1828-1828(1978)
  9. "Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. I. alpha subunit."J. Biol. Chem. 250:6735-6746(1975) [PubMed] [Europe PMC] [Abstract]
  10. "Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa)."J. Clin. Endocrinol. Metab. 39:199-202(1974) [PubMed] [Europe PMC] [Abstract]
  11. "The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit."J. Biol. Chem. 250:5247-5258(1975) [PubMed] [Europe PMC] [Abstract]
  12. "Human chorionic gonadotropin. Linear amino acid sequence of the alpha subunit."J. Biol. Chem. 248:6796-6809(1973) [PubMed] [Europe PMC] [Abstract]
  13. "Studies on the disulfide bonds in human pituitary follicle-stimulating hormone."Biochim. Biophys. Acta 624:428-435(1980) [PubMed] [Europe PMC] [Abstract]
  14. "Assignment of disulfide bonds in the alpha subunit of human chorionic gonadotropin."J. Biol. Chem. 255:8516-8522(1980) [PubMed] [Europe PMC] [Abstract]
  15. "NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin."Eur. J. Biochem. 195:257-268(1991) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of human chorionic gonadotropin."Nature 369:455-461(1994) [PubMed] [Europe PMC] [Abstract]
  17. "NMR studies of the free alpha subunit of human chorionic gonadotropin. Structural influences of N-glycosylation and the beta subunit on the conformation of the alpha subunit."Eur. J. Biochem. 241:229-242(1996) [PubMed] [Europe PMC] [Abstract]
  18. "Structure of human follicle-stimulating hormone in complex with its receptor."Nature 433:269-277(2005) [PubMed] [Europe PMC] [Abstract]