Cluster Of Differentiation 164 (CD164)

[Edit]

MGC-24v; Endolyn; CD164 Molecule,Sialomucin; Sialomucin core protein 24; Multi-glycosylated core protein 24

Cluster Of Differentiation 164 (CD164)

CD164 is a transmembrane isoform of the mucin-like glycoprotein MGC-24. MGC-24 is a 24 kDa protein rich in hydroxyl amino acids and cysteine, and lack repeating motifs identified originally in human gastric carcinoma cells as a protein binding peanut agglutinin. High levels of MGC-24 mRNA are expressed in normal tissues of the colon, small intestine and thyroid, and in some nude mouse-transplanted colorectal and pancreatic adenocarcinomas.

Kurosawa et al (1999) have reported that in the mouse only the transmembrane form is expressed in many organs. CD164 is expressed by human CD34(+) hematopoietic progenitor cells. The subpopulations of CD34(+) cells expressing CD164 include the majority of CFU-GM, BFU-E, and hierarchically more primitive precursors (pre-CFU). .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB594Hu01 Recombinant Cluster Of Differentiation 164 (CD164) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB594Hu01 Polyclonal Antibody to Cluster Of Differentiation 164 (CD164) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 164 (CD164) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 164 (CD164) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB594Mu01 Recombinant Cluster Of Differentiation 164 (CD164) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB594Mu01 Polyclonal Antibody to Cluster Of Differentiation 164 (CD164) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 164 (CD164) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 164 (CD164) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB594Ra01 Recombinant Cluster Of Differentiation 164 (CD164) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB594Ra01 Polyclonal Antibody to Cluster Of Differentiation 164 (CD164) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 164 (CD164) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 164 (CD164) ELISA Kit Customized Service Offer
  1. "A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression."J. Biochem. 112:609-615(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis."Blood 92:2613-2628(1998) [PubMed] [Europe PMC] [Abstract]
  3. "CD164 monoclonal antibodies that block hemopoietic progenitor cell adhesion and proliferation interact with the first mucin domain of the CD164 receptor."J. Immunol. 165:840-851(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn."J. Biol. Chem. 276:2139-2152(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis."BMC Cancer 6:195-195(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells."Blood 109:1825-1833(2007) [PubMed] [Europe PMC] [Abstract]