Cluster Of Differentiation 23 (CD23)
[Edit]FceRII; FCER2; BLAST-2; CLEC4J; FCE2; IGEBF; Receptor II For The Fc Region Of Immunoglobulin E; C-type lectin domain family 4 member J; Immunoglobulin E-binding factor; Lymphocyte IgE receptor
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CD23 is the "low affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin. It is found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells and platelets.
There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, while CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils and macrophages.The allergen responsible in dust mite allergy, Der-p-1, is known to cleave CD23 from a cells surface. As CD23 is soluble it can move freely and interact with cells in plasma.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB582Hu01 | Recombinant Cluster Of Differentiation 23 (CD23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB582Hu01 | Active Cluster Of Differentiation 23 (CD23) | Cell culture; Activity Assays. | |
| EPB582Hu61 | Eukaryotic Cluster Of Differentiation 23 (CD23) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APB582Hu61 | Active Cluster Of Differentiation 23 (CD23) | Cell culture; Activity Assays. | |
| Antibodies | PAB582Hu01 | Polyclonal Antibody to Cluster Of Differentiation 23 (CD23) | WB; IHC |
| MAB582Hu22 | Monoclonal Antibody to Cluster Of Differentiation 23 (CD23) | WB; IHC; ICC; IP. | |
| MAB582Hu26 | Monoclonal Antibody to Cluster Of Differentiation 23 (CD23) | WB; IHC; ICC; IP. | |
| MAB582Hu21 | Monoclonal Antibody to Cluster Of Differentiation 23 (CD23) | WB; IHC | |
| Assay Kits | SEB582Hu | ELISA Kit for Cluster Of Differentiation 23 (CD23) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB582Mu01 | Recombinant Cluster Of Differentiation 23 (CD23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB582Mu02 | Recombinant Cluster Of Differentiation 23 (CD23) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB582Mu01 | Polyclonal Antibody to Cluster Of Differentiation 23 (CD23) | WB; IHC; ICC; IP. |
| LAB582Mu71 | Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 23 (CD23) | WB; IHC; ICC. | |
| PAB582Mu02 | Polyclonal Antibody to Cluster Of Differentiation 23 (CD23) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB582Mu | ELISA Kit for Cluster Of Differentiation 23 (CD23) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | EPB582Ra61 | Eukaryotic Cluster Of Differentiation 23 (CD23) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APB582Ra61 | Active Cluster Of Differentiation 23 (CD23) | Cell culture; Activity Assays. | |
| Antibodies | n/a | Monoclonal Antibody to Cluster Of Differentiation 23 (CD23) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cluster Of Differentiation 23 (CD23) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cluster Of Differentiation 23 (CD23) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cluster Of Differentiation 23 (CD23) | ELISA Kit Customized Service Offer |
- "Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins."Proc. Natl. Acad. Sci. U.S.A. 84:819-823(1987) [PubMed] [Europe PMC] [Abstract]
- "Molecular structure of human lymphocyte receptor for immunoglobulin E."Cell 47:657-665(1986) [PubMed] [Europe PMC] [Abstract]
- "Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor."EMBO J. 6:109-114(1987) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression."Cell 55:611-618(1988) [PubMed] [Europe PMC] [Abstract]
- "Partial characterization of natural and recombinant human soluble CD23."Biochem. J. 286:819-824(1992) [PubMed] [Europe PMC] [Abstract]
- "The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10."J. Biol. Chem. 282:14836-14844(2007) [PubMed] [Europe PMC] [Abstract]
- "Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23."PLoS ONE 7:E37187-E37187(2012) [PubMed] [Europe PMC] [Abstract]
- "Modeling of the lectin-homology domains of the human and murine low-affinity Fc epsilon receptor (Fc epsilon RII/CD23)."Receptor 3:325-341(1993) [PubMed] [Europe PMC] [Abstract]
- "Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models."Protein Sci. 5:240-247(1996) [PubMed] [Europe PMC] [Abstract]
- "The structure of human CD23 and its interactions with IgE and CD21."J. Exp. Med. 202:751-760(2005) [PubMed] [Europe PMC] [Abstract]
- "Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding."Structure 14:1049-1058(2006) [PubMed] [Europe PMC] [Abstract]
- "Mutations in the autoregulatory domain of beta-tubulin 4a cause hereditary dystonia."Ann. Neurol. 73:546-553(2013) [PubMed] [Europe PMC] [Abstract]