Mucosae Associated Epithelia Chemokine (MEC)

[Edit]

CCL28; SCYA28; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 28; Chemokine C-C-Motif Ligand 28; Small-inducible cytokine A28

Mucosae Associated Epithelia Chemokine (MEC)

CCL28  is a chemokine. CCL28 regulates the chemotaxis of cells that express the chemokine receptors CCR3 and CCR10. CCL28 is expressed by columnar epithelial cells in the gut, lung, breast and the salivary glands and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3.

This chemokine is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury. CCL28 has also been implicated in the migration of IgA-expressing cells to the mammary gland, salivary gland, intestine and other mucosal tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB573Hu01 Recombinant Mucosae Associated Epithelia Chemokine (MEC) Positive Control; Immunogen; SDS-PAGE; WB.
APB573Hu01 Active Mucosae Associated Epithelia Chemokine (MEC) Cell culture; Activity Assays.
Antibodies PAB573Hu01 Polyclonal Antibody to Mucosae Associated Epithelia Chemokine (MEC) WB; IHC; ICC; IP.
MAB573Hu21 Monoclonal Antibody to Mucosae Associated Epithelia Chemokine (MEC) WB; IHC; ICC; IP.
Assay Kits SEB573Hu ELISA Kit for Mucosae Associated Epithelia Chemokine (MEC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB573Mu01 Recombinant Mucosae Associated Epithelia Chemokine (MEC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB573Mu01 Polyclonal Antibody to Mucosae Associated Epithelia Chemokine (MEC) WB; IHC; ICC; IP.
Assay Kits SEB573Mu ELISA Kit for Mucosae Associated Epithelia Chemokine (MEC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB573Ra01 Recombinant Mucosae Associated Epithelia Chemokine (MEC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB573Ra01 Polyclonal Antibody to Mucosae Associated Epithelia Chemokine (MEC) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Mucosae Associated Epithelia Chemokine (MEC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mucosae Associated Epithelia Chemokine (MEC) ELISA Kit Customized Service Offer
  1. "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)."J. Biol. Chem. 275:22313-22323(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues."J. Immunol. 165:2943-2949(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]