Killer Cell Immunoglobulin Like Receptor 2DL4 (KIR2DL4)

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CD158D; KIR2-DL4; 103AS; 15.212; KIR103; KIR103AS; G9P; Killer cell inhibitory receptor 103AS; CD158 antigen-like family member D; MHC class I NK cell receptor KIR103AS

Killer Cell Immunoglobulin Like Receptor 2DL4 (KIR2DL4)

The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. KIR2DL4  gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Killer Cell Immunoglobulin Like Receptor 2DL4 (KIR2DL4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL4 (KIR2DL4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL4 (KIR2DL4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Killer Cell Immunoglobulin Like Receptor 2DL4 (KIR2DL4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Killer Cell Immunoglobulin Like Receptor 2DL4 (KIR2DL4) ELISA Kit Customized Service Offer
  1. "NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains."Tissue Antigens 48:285-294(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors."Immunity 7:739-751(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Polymorphism and domain variability of human killer cell inhibitory receptors."Immunol. Rev. 155:183-196(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization and allelic polymorphism of the human killer cell inhibitory receptor gene KIR103."Tissue Antigens 49:564-573(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The elucidation of KIR2DL4 gene polymorphism."Mol. Immunol. 45:1900-1906(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  7. "An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]