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Lymphotoxin Beta (LTb)

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LT-B; p33; TNFC; TNF-C; TNFSF3; Tumor necrosis factor ligand superfamily member 3; Tumor Necrosis Factor C

Lymphotoxin Beta (LTb)
CCC B560
HGNC 6711
MGI 104796
PubMed 15845449
RGD 1303162
UniProt Q06643
Wiki LTB

Lymphotoxin beta (TNF superfamily, member 3), also known as LTB, is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB560Hu01 Recombinant Lymphotoxin Beta (LTb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB560Hu01 Polyclonal Antibody to Lymphotoxin Beta (LTb) WB; IHC; ICC; IP.
MAB560Hu22 Monoclonal Antibody to Lymphotoxin Beta (LTb) WB; IHC; ICC; IP.
Assay Kits SEB560Hu ELISA Kit for Lymphotoxin Beta (LTb) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB560Hu CLIA Kit for Lymphotoxin Beta (LTb) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB560Mu01 Recombinant Lymphotoxin Beta (LTb) Positive Control; Immunogen; SDS-PAGE; WB.
RPB560Mu02 Recombinant Lymphotoxin Beta (LTb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB560Mu01 Polyclonal Antibody to Lymphotoxin Beta (LTb) WB; IHC; ICC; IP.
LAB560Mu71 Biotin-Linked Polyclonal Antibody to Lymphotoxin Beta (LTb) WB; IHC; ICC.
PAB560Mu02 Polyclonal Antibody to Lymphotoxin Beta (LTb) WB; IHC; ICC; IP.
LAB560Mu81 FITC-Linked Polyclonal Antibody to Lymphotoxin Beta (LTb) WB; IHC; ICC; IF.
Assay Kits SEB560Mu ELISA Kit for Lymphotoxin Beta (LTb) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB560Mu CLIA Kit for Lymphotoxin Beta (LTb) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB560Ra01 Recombinant Lymphotoxin Beta (LTb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB560Ra01 Polyclonal Antibody to Lymphotoxin Beta (LTb) WB; IHC; ICC; IP.
MAB560Ra21 Monoclonal Antibody to Lymphotoxin Beta (LTb) WB; IHC; ICC; IP.
Assay Kits SEB560Ra ELISA Kit for Lymphotoxin Beta (LTb) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB560Ra CLIA Kit for Lymphotoxin Beta (LTb) Chemiluminescent immunoassay for Antigen Detection.
  1. "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface."Cell 72:847-856(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas."Biochem. Biophys. Res. Commun. 238:273-276(1997) [PubMed] [Europe PMC] [Abstract]
  3. "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]