Large Multifunctional Peptidase 7 (LMP7)

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PSMB8; RING10; PSMB5i, Beta5i; Proteasome(Prosome,Macropain)Subunit,Beta Type 8; Multicatalytic endopeptidase complex subunit C13; Really interesting new gene 10 protein

Large Multifunctional Peptidase 7 (LMP7)
  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

  • LMP7 encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB556Hu01 Recombinant Large Multifunctional Peptidase 7 (LMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB556Hu01 Polyclonal Antibody to Large Multifunctional Peptidase 7 (LMP7) WB; IHC; ICC; IP.
Assay Kits SEB556Hu ELISA Kit for Large Multifunctional Peptidase 7 (LMP7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB556Mu01 Recombinant Large Multifunctional Peptidase 7 (LMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB556Mu01 Polyclonal Antibody to Large Multifunctional Peptidase 7 (LMP7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Large Multifunctional Peptidase 7 (LMP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Large Multifunctional Peptidase 7 (LMP7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB556Ra01 Recombinant Large Multifunctional Peptidase 7 (LMP7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB556Ra01 Polyclonal Antibody to Large Multifunctional Peptidase 7 (LMP7) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Large Multifunctional Peptidase 7 (LMP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Large Multifunctional Peptidase 7 (LMP7) ELISA Kit Customized Service Offer
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  21. "Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis."Inflamm. Bowel Dis. 13:807-821(2007) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome."Arterioscler. Thromb. Vasc. Biol. 29:1213-1219(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Herpes simplex virus type I infection of mature dendritic cells leads to reduced LMP7-mRNA-expression levels."Immunobiology 214:861-867(2009) [PubMed] [Europe PMC] [Abstract]
  25. "A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis."Nat. Med. 15:781-787(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
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  28. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  29. "PSMB8 encoding the beta5i proteasome subunit is mutated in joint contractures, muscle atrophy, microcytic anemia, and panniculitis-induced lipodystrophy syndrome."Am. J. Hum. Genet. 87:866-872(2010) [PubMed] [Europe PMC] [Abstract]
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