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Prominin 1 (PROM1)

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CD133; PROML1; Macular Dystrophy,Retinal 2; Stargardt Disease 4(Autosomal Dominant); Prominin-like protein 1; Antigen AC133

Prominin 1 (PROM1)
CCC B516
HGNC 9454
MGI 1100886
PubMed 15558321
RGD 69367
UniProt O43490
Wiki CD133

CD133 is a glycoprotein also known in humans and rodents as Prominin 1 (PROM1).It is the founding member of pentaspan transmembrane glycoproteins (5-transmembrane, 5-TM), which specifically localizes to cellular protrusions. CD133 is expressed in hematopoietic stem cells, endothelial progenitor cells, glioblastomas, neuronal and glial stem cells and some other cell types.

In contrast, AC133-1 was prominent in fetal brain and adult skeletal muscle and absent in fetal liver and kidney and in adult pancreas, kidney, bone marrow, hematopoietic stem cells, and placenta. RT-PCR and flow cytometric analysis revealed expression of AC133-2 in basal epidermal stem cells, and the expression was downregulated in cultured basal cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB516Hu01 Recombinant Prominin 1 (PROM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB516Hu01 Polyclonal Antibody to Prominin 1 (PROM1) WB; IHC; ICC; IP.
MAB516Hu22 Monoclonal Antibody to Prominin 1 (PROM1) WB; IHC; ICC; IP.
LAB516Hu71 Biotin-Linked Polyclonal Antibody to Prominin 1 (PROM1) WB; IHC; ICC.
LAB516Hu82 FITC-Linked Monoclonal Antibody to Prominin 1 (PROM1) WB; IHC; ICC; IF.
LAB516Hu81 FITC-Linked Polyclonal Antibody to Prominin 1 (PROM1) WB; IHC; ICC; IF.
Assay Kits SEB516Hu ELISA Kit for Prominin 1 (PROM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB516Mu01 Recombinant Prominin 1 (PROM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB516Mu01 Polyclonal Antibody to Prominin 1 (PROM1) WB; IHC; ICC; IP.
LAB516Mu71 Biotin-Linked Polyclonal Antibody to Prominin 1 (PROM1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Prominin 1 (PROM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prominin 1 (PROM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prominin 1 (PROM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prominin 1 (PROM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prominin 1 (PROM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prominin 1 (PROM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prominin 1 (PROM1) ELISA Kit Customized Service Offer
  1. "A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning."Blood 90:5013-5021(1997) [PubMed] [Europe PMC] [Abstract]
  2. "AC133-2, a novel isoform of human AC133 stem cell antigen."J. Biol. Chem. 277:20711-20716(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "AC133, a novel marker for human hematopoietic stem and progenitor cells."Blood 90:5002-5012(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Differential expression of prominin-1 (CD133) and prominin-2 in major cephalic exocrine glands of adult mice."Histochem. Cell Biol. 128:409-419(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Nomenclature of prominin-1 (CD133) splice variants - an update."Tissue Antigens 69:602-606(2007) [PubMed] [Europe PMC] [Abstract]
  9. "The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease." Stem Cells 26:698-705(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol."FEBS Lett. 583:897-902(2009) [PubMed] [Europe PMC] [Abstract]
  11. "CD133 suppresses neuroblastoma cell differentiation via signal pathway modification."Oncogene 30:97-105(2011) [PubMed] [Europe PMC] [Abstract]
  12. "A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration."Hum. Mol. Genet. 9:27-34(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Severe retinitis pigmentosa mapped to 4p15 and associated with a novel mutation in the PROM1 gene."Hum. Genet. 122:293-299(2007) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation."J. Mol. Biol. 426:2175-2182(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice." J. Clin. Invest. 118:2908-2916(2008) [PubMed] [Europe PMC] [Abstract]