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Pitrilysin Metalloproteinase 1 (MP1)

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PITRM1; hMP1; PreP; PreP Peptidasome; Presequence protease, mitochondrial; Metalloprotease 1

Pitrilysin Metalloproteinase 1 (MP1)
CCC B473
HGNC 17663
MGI 1916867
PubMed 15919810
RGD 1310998
UniProt Q5JRX3
Wiki MP1

The phosphofructokinase (PFK) C (Pfkp) and the pitrilysin metalloprotease 1 (Pitrm1) genes are compelling positional candidate genes in this region that show coding sequence differences between the parental strains in functional domains.

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB473Hu01 Recombinant Pitrilysin Metalloproteinase 1 (MP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB473Hu01 Polyclonal Antibody to Pitrilysin Metalloproteinase 1 (MP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pitrilysin Metalloproteinase 1 (MP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pitrilysin Metalloproteinase 1 (MP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pitrilysin Metalloproteinase 1 (MP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pitrilysin Metalloproteinase 1 (MP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pitrilysin Metalloproteinase 1 (MP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pitrilysin Metalloproteinase 1 (MP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pitrilysin Metalloproteinase 1 (MP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB473Ra01 Recombinant Pitrilysin Metalloproteinase 1 (MP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB473Ra01 Polyclonal Antibody to Pitrilysin Metalloproteinase 1 (MP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Pitrilysin Metalloproteinase 1 (MP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pitrilysin Metalloproteinase 1 (MP1) ELISA Kit Customized Service Offer
  1. "Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases."DNA Cell Biol. 18:369-380(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP."J. Biol. Chem. 281:29096-29104(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Mammalian pitrilysin: substrate specificity and mitochondrial targeting."Biochemistry 48:2868-2877(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]