Connexin 31 (CX31)

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family that includes GJB3. Gap junction beta-3 protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB467Hu01 Recombinant Connexin 31 (CX31) Positive Control; Immunogen; SDS-PAGE; WB.
RPB467Hu02 Recombinant Connexin 31 (CX31) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB467Hu02 Polyclonal Antibody to Connexin 31 (CX31) WB; IHC; ICC; IP.
PAB467Hu01 Polyclonal Antibody to Connexin 31 (CX31) WB; IHC; ICC; IP.
LAB467Hu71 Biotin-Linked Polyclonal Antibody to Connexin 31 (CX31) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Connexin 31 (CX31) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connexin 31 (CX31) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB467Mu01 Recombinant Connexin 31 (CX31) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB467Mu01 Polyclonal Antibody to Connexin 31 (CX31) WB; IHC; ICC; IP.
LAB467Mu71 Biotin-Linked Polyclonal Antibody to Connexin 31 (CX31) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Connexin 31 (CX31) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connexin 31 (CX31) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB467Ra01 Recombinant Connexin 31 (CX31) Positive Control; Immunogen; SDS-PAGE; WB.
RPB467Ra02 Recombinant Connexin 31 (CX31) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB467Ra01 Polyclonal Antibody to Connexin 31 (CX31) WB; IHC; ICC; IP.
LAB467Ra71 Biotin-Linked Polyclonal Antibody to Connexin 31 (CX31) WB; IHC; ICC.
PAB467Ra02 Polyclonal Antibody to Connexin 31 (CX31) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Connexin 31 (CX31) CLIA Kit Customized Service Offer
n/a ELISA Kit for Connexin 31 (CX31) ELISA Kit Customized Service Offer
  1. "Human gap junction protein connexin31: molecular cloning and expression analysis."Biochem. Biophys. Res. Commun. 248:910-915(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis."Nat. Genet. 20:366-369(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in the gene encoding gap junction protein beta-3 associated with autosomal dominant hearing impairment."Nat. Genet. 20:370-373(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a novel mutation R42P in the gap junction protein beta-3 associated with autosomal dominant erythrokeratoderma variabilis."J. Invest. Dermatol. 113:1119-1122(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Connexin mutations associated with palmoplantar keratoderma and profound deafness in a single family."Eur. J. Hum. Genet. 8:141-144(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The spectrum of mutations in erythrokeratodermias -- novel and de novo mutations in GJB3."Hum. Genet. 106:321-329(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of seven novel SNPS (five nucleotide and two amino acid substitutions) in the connexin31 (GJB3) gene."Hum. Mutat. 15:481-482(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Connexin mutations in Brazilian patients with skin disorders with or without hearing loss."Am. J. Med. Genet. A 149:681-684(2009) [PubMed] [Europe PMC] [Abstract]