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Semaphorin 7A (SEMA7A)

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CD108; CDw108; H-SEMA-K1; H-Sema-L; JMH; SEMAK1; SEMAL; Semaphorin 7A,GPI Membrane Anchor; John Milton Hagen Blood Group; Semaphorin-K1; Semaphorin-L

Semaphorin 7A (SEMA7A)
CCC B448
HGNC 10741
MGI 1306826
PubMed 12193228
RGD 1305192
UniProt O75326
Wiki SEMA7A

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.

Czopik et al. (2006) found that T cells from immunized Sema7a -/- mice had increased proliferative responses to antigen that were not attributable to Sema7a deficiency on macrophages or dendritic cells. Sema7a -/- mice were prone to die at the onset of experimental autoimmune encephalomyelitis (EAE) and had higher clinical EAE scores compared with wildtype littermates. Delayed-type hypersensitivity responses were also enhanced in Sema7a -/- mice.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB448Hu01 Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB448Hu01 Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
MAB448Hu22 Monoclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
Assay Kits SEB448Hu ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB448Mu01 Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
RPB448Mu02 Recombinant Semaphorin 7A (SEMA7A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB448Mu01 Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
PAB448Mu02 Polyclonal Antibody to Semaphorin 7A (SEMA7A) WB; IHC; ICC; IP.
Assay Kits SEB448Mu ELISA Kit for Semaphorin 7A (SEMA7A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Semaphorin 7A (SEMA7A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Semaphorin 7A (SEMA7A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Semaphorin 7A (SEMA7A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Semaphorin 7A (SEMA7A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Semaphorin 7A (SEMA7A) ELISA Kit Customized Service Offer
  1. "New eukaryotic semaphorins with close homology to semaphorins of DNA viruses."Genomics 51:340-350(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108."J. Immunol. 162:4094-4100(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins."J. Biol. Chem. 273:22428-22434(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens."Transfusion 47:133-146(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules."Immunobiology 200:234-245(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Semaphorin 7A promotes axon outgrowth through integrins and MAPKs."Nature 424:398-405(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin."Nature 446:680-684(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins."J. Invest. Dermatol. 128:151-161(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1."Cell 142:749-761(2010) [PubMed] [Europe PMC] [Abstract]
  13. "A new SEMA7A variant found in Native Americans with alloantibody."Vox Sang. 100:322-326(2011) [PubMed] [Europe PMC] [Abstract]