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Acetylcholinesterase (ACHE)

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ARAChE; N-AChE; YT

Acetylcholinesterase (ACHE)
CCC B447
HGNC 108
MGI 87876
PubMed 11283752
RGD 69313
UniProt P22303
Wiki ACHE

Acetylcholinesterase is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. It is mainly found at neuromuscular junctions and cholinergic synapses in the central nervous system, where its activity serves to terminate synaptic transmission.

AChE has a very high catalytic activity mdash; each molecule of AChE degrades about 5000 molecules of acetylcholine per second. The choline produced by the action of AChE is recycled mdash; it is transported, through reuptake, back into nerve terminals where it is used to synthesize new acetylcholine molecules.Acetylcholinesterase is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB447Hu01 Recombinant Acetylcholinesterase (ACHE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB447Hu01 Polyclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC; IP.
LAB447Hu71 Biotin-Linked Polyclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC.
MAB447Hu21 Monoclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC; IP.
MAB447Hu22 Monoclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC; IP.
MAB447Hu23 Monoclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC; IP.
MAB447Hu24 Monoclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC; IP.
MAB447Hu25 Monoclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC; IP.
Assay Kits SEB447Hu ELISA Kit for Acetylcholinesterase (ACHE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB447Mu01 Recombinant Acetylcholinesterase (ACHE) Positive Control; Immunogen; SDS-PAGE; WB.
RPB447Mu02 Recombinant Acetylcholinesterase (ACHE) Positive Control; Immunogen; SDS-PAGE; WB.
EPB447Mu61 Eukaryotic Acetylcholinesterase (ACHE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB447Mu01 Polyclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC; IP.
PAB447Mu02 Polyclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC; IP.
LAB447Mu71 Biotin-Linked Polyclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC.
Assay Kits SEB447Mu ELISA Kit for Acetylcholinesterase (ACHE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB447Ra01 Recombinant Acetylcholinesterase (ACHE) Positive Control; Immunogen; SDS-PAGE; WB.
RPB447Ra02 Recombinant Acetylcholinesterase (ACHE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB447Ra01 Polyclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC; IP.
PAB447Ra02 Polyclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC; IP.
LAB447Ra71 Biotin-Linked Polyclonal Antibody to Acetylcholinesterase (ACHE) WB; IHC; ICC.
Assay Kits SEB447Ra ELISA Kit for Acetylcholinesterase (ACHE) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB447Bo01 Recombinant Acetylcholinesterase (ACHE) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Acetylcholinesterase (ACHE) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Acetylcholinesterase (ACHE) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Acetylcholinesterase (ACHE) CLIA Kit Customized Service Offer
n/a ELISA Kit for Acetylcholinesterase (ACHE) ELISA Kit Customized Service Offer
  1. "Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure."Proc. Natl. Acad. Sci. U.S.A. 87:9688-9692(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins."Exp. Cell Res. 210:268-277(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase."FEBS Lett. 247:279-282(1989) [PubMed] [Europe PMC] [Abstract]
  8. "The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580-->Ala mutant."J. Biol. Chem. 266:23977-23984(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding."J. Biol. Chem. 267:17640-17648(1992) [PubMed] [Europe PMC] [Abstract]
  10. "Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells."Neurosci. Res. 42:261-268(2002) [PubMed] [Europe PMC] [Abstract]
  11. "External and internal electrostatic potentials of cholinesterase models."J. Mol. Graph. Model. 15:318-327(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II."Acta Crystallogr. D 56:1385-1394(2000) [PubMed] [Europe PMC] [Abstract]
  13. "The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix."EMBO J. 23:4394-4405(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation."J. Med. Chem. 53:4002-4008(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Structures of human acetylcholinesterase in complex with pharmacologically important ligands."J. Med. Chem. 55:10282-10286(2012) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase."Biochem. J. 453:393-399(2013) [PubMed] [Europe PMC] [Abstract]
  17. "Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism."Am. J. Hum. Genet. 52:928-936(1993) [PubMed] [Europe PMC] [Abstract]