Tyrosine Hydroxylase (TH)

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TYH; DYT5b; Tyrosine 3-Monooxygenase; Dystonia 14

Tyrosine Hydroxylase (TH)

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to dihydroxyphenylalanine (DOPA). DOPA is a precursor for dopamine which in turn is a precursor for norepinephrine (noradrenaline) and epinephrine (adrenaline).

In humans, tyrosine hydroxylase is encoded by the TH gene.The enzyme, an oxygenase, is found in the cytosol of all cells containing catecholamines. This initial reaction is the rate limiting step in the production of catecholamines.The enzyme is highly specific, not accepting indole derivatives - which is unusual as many other enzymes involved in the production of catecholamines do.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB438Hu01 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB438Hu01 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu22 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu21 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu24 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu25 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
Assay Kits SEB438Hu ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB438Mi ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB438Mu01 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
RPB438Mu02 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB438Mu01 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
PAB438Mu02 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
Assay Kits SEB438Mi ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB438Mu ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB438Ra01 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB438Ra01 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
LAB438Ra71 Biotin-Linked Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC.
MAB438Ra21 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Ra22 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Ra27 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Ra23 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Ra24 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Ra25 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
Assay Kits SEB438Ra ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB438Ra CLIA Kit for Tyrosine Hydroxylase (TH) Chemiluminescent immunoassay for Antigen Detection.
SEB438Mi ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB438Bo01 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB438Bo01 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tyrosine Hydroxylase (TH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosine Hydroxylase (TH) ELISA Kit Customized Service Offer
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  21. ErratumNat. Genet. 23:373-373(1999)
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  25. "Levodopa-responsive infantile parkinsonism due to a novel mutation in the tyrosine hydroxylase gene and exacerbation by viral infections."Mov. Disord. 20:764-767(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Pre- and postnatal diagnosis of tyrosine hydroxylase deficiency."Prenat. Diagn. 25:671-675(2005) [PubMed] [Europe PMC] [Abstract]
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  30. "Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia." Brain 132:1753-1763(2009) [PubMed] [Europe PMC] [Abstract]
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