Complement Component 1, Q Receptor (C1qR1)

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CDw93; CD93; C1qRP; C1q-R; MXRA4; Matrix-remodeling-associated protein 4; CD93 Antigen; C1q/MBL/SPA receptor; Complement component 1 q subcomponent receptor 1

Complement Component 1, Q Receptor (C1qR1)

CD93 is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.Cluster of Differentiation 93 is a receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB405Hu01 Recombinant Complement Component 1, Q Receptor (C1qR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB405Hu01 Polyclonal Antibody to Complement Component 1, Q Receptor (C1qR1) WB; IHC; ICC; IP.
MAB405Hu21 Monoclonal Antibody to Complement Component 1, Q Receptor (C1qR1) WB; IHC; ICC; IP.
MAB405Hu22 Monoclonal Antibody to Complement Component 1, Q Receptor (C1qR1) WB; IHC; ICC; IP.
MAB405Hu25 Monoclonal Antibody to Complement Component 1, Q Receptor (C1qR1) WB; IHC; ICC; IP.
MAB405Hu24 Monoclonal Antibody to Complement Component 1, Q Receptor (C1qR1) WB; IHC; ICC; IP.
MAB405Hu23 Monoclonal Antibody to Complement Component 1, Q Receptor (C1qR1) WB; IHC; ICC; IP.
Assay Kits SEB405Hu ELISA Kit for Complement Component 1, Q Receptor (C1qR1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB405Mu01 Recombinant Complement Component 1, Q Receptor (C1qR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB405Mu01 Polyclonal Antibody to Complement Component 1, Q Receptor (C1qR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Complement Component 1, Q Receptor (C1qR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 1, Q Receptor (C1qR1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB405Ra01 Recombinant Complement Component 1, Q Receptor (C1qR1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB405Ra01 Polyclonal Antibody to Complement Component 1, Q Receptor (C1qR1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Complement Component 1, Q Receptor (C1qR1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Component 1, Q Receptor (C1qR1) ELISA Kit Customized Service Offer
  1. "cDNA cloning and primary structure analysis of C1qR(P), the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro."Immunity 6:119-129(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning."J. Leukoc. Biol. 71:133-140(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex."J. Immunol. 159:1429-1436(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q."J. Immunol. 168:5222-5232(2002) [PubMed] [Europe PMC] [Abstract]
  7. "C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity."J. Immunol. 162:3583-3589(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation."J. Clin. Invest. 106:1239-1249(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]