Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4)

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CD85k; LILR-B4; LILRB5; HM18; ILT3; LIR-5; Immunoglobulin-like transcript 3; Leukocyte immunoglobulin-like receptor 5; CD85 antigen-like family member K

Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4)
Leukocyte immunoglobulin-like receptor subfamily B member 4is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB399Hu01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB399Hu01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
MAB399Hu22 Monoclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
Assay Kits SEB399Hu ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB399Mu01 Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB399Mu01 Polyclonal Antibody to Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 4 (LILRB4) ELISA Kit Customized Service Offer
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  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance."J. Biol. Chem. 286:18013-18025(2011) [PubMed] [Europe PMC] [Abstract]