Involucrin (iNV)

Involucrin is a protein component of human skin. In binding the protein loricrin, involucrin contributes to the formation of a cell envelope that protects corneocytes in the skin.It is the Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Expressed in keratinocytes of epidermis and other stratified squamous epithelia.

Involucrin is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. It first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane functioning as a glutamyl donor during assembly of the cornified envelope.

Involucrin is synthesised in the stratum spinosum and cross linked in the stratum granulosum by the transglutaminase enzyme that makes it highly stable. Thus it provides structural support to the cell, thereby allowing the cell to resist invasion by micro-organisms.

Apigenin, a plant-derived flavanoid that has significant promise as a skin cancer chemopreventiveagent, has been found to regulate normal human keratinocyte differentiation by suppressing involucrin, and this is associated with reduced cell proliferation without apoptosis.


Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB331Hu01 Recombinant Involucrin (iNV) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB331Hu01 Polyclonal Antibody to Involucrin (iNV) WB; IHC; ICC; IP.
MAB331Hu22 Monoclonal Antibody to Involucrin (iNV) WB; IHC; ICC; IP.
Assay Kits SEB331Hu ELISA Kit for Involucrin (iNV) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB331Mu01 Recombinant Involucrin (iNV) Positive Control; Immunogen; SDS-PAGE; WB.
RPB331Mu02 Recombinant Involucrin (iNV) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB331Mu01 Polyclonal Antibody to Involucrin (iNV) WB; IHC; ICC; IP.
PAB331Mu02 Polyclonal Antibody to Involucrin (iNV) WB; IHC; ICC; IP.
Assay Kits SEB331Mu ELISA Kit for Involucrin (iNV) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB331Ra01 Recombinant Involucrin (iNV) Positive Control; Immunogen; SDS-PAGE; WB.
RPB331Ra02 Recombinant Involucrin (iNV) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB331Ra01 Polyclonal Antibody to Involucrin (iNV) WB; IHC; ICC; IP.
PAB331Ra02 Polyclonal Antibody to Involucrin (iNV) WB; IHC; ICC; IP.
LAB331Ra71 Biotin-Linked Polyclonal Antibody to Involucrin (iNV) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Involucrin (iNV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Involucrin (iNV) ELISA Kit Customized Service Offer
  1. "Structure and evolution of the human involucrin gene."Cell 46:583-589(1986) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes."J. Biol. Chem. 272:12035-12046(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope."J. Biol. Chem. 267:12233-12238(1992) [PubMed] [Europe PMC] [Abstract]
  6. "The glutamine residues reactive in transglutaminase-catalyzed cross-linking of involucrin."J. Biol. Chem. 263:18093-18098(1988) [PubMed] [Europe PMC] [Abstract]
  7. "Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope."J. Biol. Chem. 273:17763-17770(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and characterization of a novel component of the cornified envelope, cornifelin."Biochem. Biophys. Res. Commun. 318:803-813(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]