≡

Caldesmon (CALD)

[Edit]

CALD1; CDM; H-CAD; L-CAD; NAG22

Caldesmon (CALD)
CCC B324
HGNC 1441
MGI 88250
PubMed 14755551
RGD 2256
UniProt Q05682
Wiki Caldesmon

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca -calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca -dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB324Hu01 Recombinant Caldesmon (CALD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB324Hu01 Polyclonal Antibody to Caldesmon (CALD) WB; IHC
MAB324Hu21 Monoclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
Assay Kits SEB324Hu ELISA Kit for Caldesmon (CALD) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Caldesmon (CALD) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Caldesmon (CALD) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Caldesmon (CALD) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Caldesmon (CALD) CLIA Kit Customized Service Offer
n/a ELISA Kit for Caldesmon (CALD) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB324Ra01 Recombinant Caldesmon (CALD) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB324Ra01 Polyclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
MAB324Ra21 Monoclonal Antibody to Caldesmon (CALD) WB; IHC; ICC; IP.
Assay Kits SEB324Ra ELISA Kit for Caldesmon (CALD) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells."J. Biol. Chem. 266:16917-16924(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of cDNAs encoding human caldesmons."Gene 112:197-204(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic structure of the human caldesmon gene."Proc. Natl. Acad. Sci. U.S.A. 89:12122-12126(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of functioning regulatory sites and a new myosin binding site in the C-terminal 288 amino acids of caldesmon expressed from a human clone."J. Muscle Res. Cell Motil. 14:385-391(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]