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Agrin (AGRN)

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Agrin Proteoglycan

Agrin (AGRN)
CCC B303
HGNC 329
MGI 87961
PubMed 9015340
RGD 2067
UniProt O00468
Wiki Agrin

Agrin is a large proteoglycan whose best characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis.  This protein has nine domains homologous to protease inhibitors. It may also have functions in other tissues and during other stages of development.

It is major proteoglycan component in glomerular basement membrane and may play a role in the renal filtration and cell-matrix interactions.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ) is called the MuSK receptor (Muscle specific kinase).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB303Hu01 Recombinant Agrin (AGRN) Positive Control; Immunogen; SDS-PAGE; WB.
RPB303Hu02 Recombinant Agrin (AGRN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB303Hu01 Polyclonal Antibody to Agrin (AGRN) WB; IHC; ICC; IP.
MAB303Hu22 Monoclonal Antibody to Agrin (AGRN) WB; IHC; ICC; IP.
PAB303Hu02 Polyclonal Antibody to Agrin (AGRN) WB; IHC; ICC; IP.
Assay Kits SEB303Hu ELISA Kit for Agrin (AGRN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB303Mu01 Recombinant Agrin (AGRN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB303Mu01 Polyclonal Antibody to Agrin (AGRN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Agrin (AGRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Agrin (AGRN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB303Ra01 Recombinant Agrin (AGRN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB303Ra01 Polyclonal Antibody to Agrin (AGRN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Agrin (AGRN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Agrin (AGRN) ELISA Kit Customized Service Offer
  1. "Primary structure and high expression of human agrin in basement membranes of adult lung and kidney."Eur. J. Biochem. 254:123-128(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Agrin binds to the nerve-muscle basal lamina via laminin."J. Cell Biol. 137:671-683(1997) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein."Mol. Cell. Neurosci. 17:208-225(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of agrinSN isoform and muscle-specific receptor tyrosine kinase (MuSK) in sperm."Biochem. Biophys. Res. Commun. 342:522-528(2006) [PubMed] [Europe PMC] [Abstract]
  7. ErratumBiochem. Biophys. Res. Commun. 344:453-453(2006)
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Proteomics characterization of extracellular space components in the human aorta."Mol. Cell. Proteomics 9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)."J. Biol. Chem. 286:40624-40630(2011) [PubMed] [Europe PMC] [Abstract]
  11. "C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction."Exp. Gerontol. 48:76-80(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of an agrin mutation that causes congenital myasthenia and affects synapse function." Am. J. Hum. Genet. 85:155-167(2009) [PubMed] [Europe PMC] [Abstract]
  13. Erratum Am. J. Hum. Genet. 85:536-536(2009)
  14. "LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z-) agrin."Hum. Genet. 131:1123-1135(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Agrin mutations lead to a congenital myasthenic syndrome with distal muscle weakness and atrophy." Brain 137:2429-2443(2014) [PubMed] [Europe PMC] [Abstract]