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Cluster of Differentiation 42d (CD42d)

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CD42-D; GP5; Glycoprotein V, Platelet

Cluster of Differentiation 42d (CD42d)
CCC B300
HGNC 4443
MGI 1096363
PubMed 11493449
RGD 2724
UniProt P40197
Wiki GP5

Glycoprotein V (platelet) (GP5) also known as CD42d (Cluster of Differentiation 42d), is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis.

The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA) and a beta chain (GP1BB), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome , a bleeding disorder.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB300Hu01 Recombinant Cluster of Differentiation 42d (CD42d) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB300Hu01 Polyclonal Antibody to Cluster of Differentiation 42d (CD42d) WB,FCM
MAB300Hu22 Monoclonal Antibody to Cluster of Differentiation 42d (CD42d) WB; IHC; ICC; IP.
Assay Kits SEB300Hu ELISA Kit for Cluster of Differentiation 42d (CD42d) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB300Mu01 Recombinant Cluster of Differentiation 42d (CD42d) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB300Mu01 Polyclonal Antibody to Cluster of Differentiation 42d (CD42d) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster of Differentiation 42d (CD42d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 42d (CD42d) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cluster of Differentiation 42d (CD42d) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cluster of Differentiation 42d (CD42d) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cluster of Differentiation 42d (CD42d) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cluster of Differentiation 42d (CD42d) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster of Differentiation 42d (CD42d) ELISA Kit Customized Service Offer
  1. "Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins."Proc. Natl. Acad. Sci. U.S.A. 90:8327-8331(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation."J. Biol. Chem. 268:20801-20807(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib."Blood 75:2349-2356(1990) [PubMed] [Europe PMC] [Abstract]
  4. "Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion."Biochem. Biophys. Res. Commun. 170:153-161(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]