Membrane Cofactor Protein (MCP)

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CD46; MIC10; TLX; TRA2; Trophoblast leukocyte common antigen; CD46 Molecule,Complement Regulatory Protein; CD46 Molecule,Complement Regulatory protein

Membrane Cofactor Protein (MCP)
CD46 complement regulatory protein also known as CD46 ( is a protein which is encoded by the CD46 gene. CD46(MCP;MIC10) is an inhibitory complement receptor.This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. The protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB275Hu01 Recombinant Membrane Cofactor Protein (MCP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB275Hu01 Polyclonal Antibody to Membrane Cofactor Protein (MCP) WB; IHC; ICC; IP.
MAB275Hu22 Monoclonal Antibody to Membrane Cofactor Protein (MCP) WB; IHC; ICC; IP.
LAB275Hu71 Biotin-Linked Polyclonal Antibody to Membrane Cofactor Protein (MCP) WB; IHC; ICC.
Assay Kits SEB275Hu ELISA Kit for Membrane Cofactor Protein (MCP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB275Mu01 Recombinant Membrane Cofactor Protein (MCP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB275Mu01 Polyclonal Antibody to Membrane Cofactor Protein (MCP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Membrane Cofactor Protein (MCP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Cofactor Protein (MCP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB275Ra01 Recombinant Membrane Cofactor Protein (MCP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB275Ra01 Polyclonal Antibody to Membrane Cofactor Protein (MCP) WB; IHC; ICC; IP.
LAB275Ra81 FITC-Linked Polyclonal Antibody to Membrane Cofactor Protein (MCP) WB; IHC; ICC; IF.
LAB275Ra71 Biotin-Linked Polyclonal Antibody to Membrane Cofactor Protein (MCP) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Membrane Cofactor Protein (MCP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Cofactor Protein (MCP) ELISA Kit Customized Service Offer
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  21. "Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria."Mol. Microbiol. 25:639-647(1997) [PubMed] [Europe PMC] [Abstract]
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  27. "Attachment of Neisseria gonorrhoeae to the cellular pilus receptor CD46: identification of domains important for bacterial adherence."Cell. Microbiol. 3:133-143(2001) [PubMed] [Europe PMC] [Abstract]
  28. "Human Herpesvirus 6 and Measles Virus employ distinct CD46 domains for receptor function."J. Biol. Chem. 277:39112-39118(2002) [PubMed] [Europe PMC] [Abstract]
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  31. "Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa."Mol. Reprod. Dev. 62:534-546(2002) [PubMed] [Europe PMC] [Abstract]
  32. "Interaction of glycoprotein H of human herpesvirus 6 with the cellular receptor CD46."J. Biol. Chem. 278:25964-25969(2003) [PubMed] [Europe PMC] [Abstract]
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  35. "Adenovirus type 11 uses CD46 as a cellular receptor."J. Virol. 77:9183-9191(2003) [PubMed] [Europe PMC] [Abstract]
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  37. "Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype."Nature 421:388-392(2003) [PubMed] [Europe PMC] [Abstract]
  38. "CD46 is a cellular receptor for group B adenoviruses."Nat. Med. 9:1408-1412(2003) [PubMed] [Europe PMC] [Abstract]
  39. "Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form."Eur. J. Immunol. 34:2620-2629(2004) [PubMed] [Europe PMC] [Abstract]
  40. "Membrane cofactor protein is a receptor for adenoviruses associated with epidemic keratoconjunctivitis."J. Virol. 78:3897-3905(2004) [PubMed] [Europe PMC] [Abstract]
  41. "The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3."J. Virol. 78:4454-4462(2004) [PubMed] [Europe PMC] [Abstract]
  42. "Localization of regions in CD46 that interact with adenovirus."J. Virol. 79:7503-7513(2005) [PubMed] [Europe PMC] [Abstract]
  43. "CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7."J. Virol. 79:14429-14436(2005) [PubMed] [Europe PMC] [Abstract]
  44. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  45. "Crystal structure of two CD46 domains reveals an extended measles virus-binding surface."EMBO J. 18:2911-2922(1999) [PubMed] [Europe PMC] [Abstract]
  46. "Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome."Proc. Natl. Acad. Sci. U.S.A. 100:12966-12971(2003) [PubMed] [Europe PMC] [Abstract]
  47. "Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome."Blood 108:1267-1279(2006) [PubMed] [Europe PMC] [Abstract]
  48. "Insights into hemolytic uremic syndrome: segregation of three independent predisposition factors in a large, multiple affected pedigree."Mol. Immunol. 43:1769-1775(2006) [PubMed] [Europe PMC] [Abstract]
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