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Glucagon (GCG)

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GC; GLP1; GLP2; GRPP; Glicentin-Related Polypeptide; Glucagen; Oxyntomodulin; Incretin hormone

Glucagon (GCG)
CCC B266
HGNC 4191
MGI 95674
PubMed 12626323
RGD 2668
UniProt P01275
Wiki Glucagon

Glucagon has a major role in maintaining normal concentrations of glucose in blood, and is often described as having the opposite effect of insulin. That is, glucagon has the effect of increasing blood glucose levels. Glucagon is a linear peptide of 29 amino acids. Its primary sequence is almost perfectly conserved among vertebrates, and it is structurally related to the secretin family of peptide hormones.

Glucagon is synthesized as proglucagon and proteolytically processed to yield glucagon within alpha cells of the pancreatic islets. Proglucagon is also expressed within the intestinal tract, where it is processed not into glucagon, but to a family of glucagon-like peptides (enteroglucagon).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB266Hu01 Recombinant Glucagon (GCG) Positive Control; Immunogen; SDS-PAGE; WB.
CPB266Hu21 OVA Conjugated Glucagon (GCG) Immunogen; SDS-PAGE; WB.
Antibodies PAB266Hu01 Polyclonal Antibody to Glucagon (GCG) WB; IHC; ICC; IP.
MAB266Hu22 Monoclonal Antibody to Glucagon (GCG) WB; IHC; ICC; IP.
MAB266Hu21 Monoclonal Antibody to Glucagon (GCG) WB; IHC; ICC; IP.
Assay Kits CEB266Hu ELISA Kit for Glucagon (GCG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB266Mu01 Recombinant Glucagon (GCG) Positive Control; Immunogen; SDS-PAGE; WB.
RPB266Mu02 Recombinant Glucagon (GCG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB266Mu01 Polyclonal Antibody to Glucagon (GCG) WB; IHC; ICC; IP.
PAB266Mu02 Polyclonal Antibody to Glucagon (GCG) WB; IHC; ICC; IP.
Assay Kits CEB266Mu ELISA Kit for Glucagon (GCG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB266Ra01 Recombinant Glucagon (GCG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB266Ra01 Polyclonal Antibody to Glucagon (GCG) WB; IHC; ICC; IP.
MAB266Ra21 Monoclonal Antibody to Glucagon (GCG) WB; IHC; ICC; IP.
Assay Kits CEB266Ra ELISA Kit for Glucagon (GCG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucagon (GCG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucagon (GCG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucagon (GCG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glucagon (GCG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glucagon (GCG) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucagon (GCG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glucagon (GCG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glucagon (GCG) Polyclonal Antibody Customized Service Offer
Assay Kits CEB266Po ELISA Kit for Glucagon (GCG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB266Ga01 Recombinant Glucagon (GCG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB266Ga01 Polyclonal Antibody to Glucagon (GCG) WB; IHC; ICC; IP.
MAB266Ga21 Monoclonal Antibody to Glucagon (GCG) WB; IHC; ICC; IP.
Assay Kits CEB266Ga ELISA Kit for Glucagon (GCG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Pan-species (General)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glucagon (GCG) Recombinant Protein Customized Service Offer
Antibodies PAB266Ge01 Polyclonal Antibody to Glucagon (GCG) WB; IHC; ICC; IP.
Assay Kits CEB266Ge ELISA Kit for Glucagon (GCG) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "Structure of the human glucagon gene."Nucleic Acids Res. 14:4719-4730(1986) [PubMed] [Europe PMC] [Abstract]
  3. "Exon duplication and divergence in the human preproglucagon gene."Nature 304:368-371(1983) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  8. "Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable."Diabetes 42:658-661(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Oxyntomodulin suppresses appetite and reduces food intake in humans."J. Clin. Endocrinol. Metab. 88:4696-4701(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Postnatal and postprandial changes in plasma concentrations of glicentin in term and preterm infants."Acta Paediatr. 92:1175-1179(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Role of the prohormone convertase PC2 in the processing of proglucagon to glucagon."FEBS Lett. 413:119-123(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Expression, purification, and PC1-mediated processing of human proglucagon, glicentin, and major proglucagon fragment."Protein Expr. Purif. 28:15-24(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2."Can. J. Physiol. Pharmacol. 81:1005-1012(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis."Mol. Endocrinol. 17:161-171(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Glucagon and regulation of glucose metabolism."Am. J. Physiol. 284:E671-E678(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Glucagon-like peptide 2."Trends Endocrinol. Metab. 10:153-156(1999) [PubMed] [Europe PMC] [Abstract]
  17. "The glucagon-like peptides."Endocr. Rev. 20:876-913(1999) [PubMed] [Europe PMC] [Abstract]
  18. "Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity."J. Med. Chem. 41:2693-2700(1998) [PubMed] [Europe PMC] [Abstract]
  19. "NMR studies of the aggregation of glucagon-like peptide-1: formation of a symmetric helical dimer."FEBS Lett. 515:165-170(2002) [PubMed] [Europe PMC] [Abstract]
  20. "NMR solution structure of the glucagon antagonist [desHis1, desPhe6, Glu9]glucagon amide in the presence of perdeuterated dodecylphosphocholine micelles."Biochemistry 42:2825-2835(2003) [PubMed] [Europe PMC] [Abstract]