Keratin 20 (KRT20)

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CK20; Cytokeratin 20; Protein IT; Keratin, type I cytoskeletal 20

Keratin 20 (KRT20)

Cytokeratin 20(CK20) is a major cellular protein of mature enterocytes and goblet cells commonly found in mucosal epithelium of the mammalian gastrointestinal tract. Results strongly suggest that transcriptional regulation of keratin genes in the intestinal epithelium occurs at the level of both immature and terminally differentiated epithelial cells, and is tightly regulated during both fetal development and crypt-to-villus differentiation of the intestinal epithelium.

CK20 has recently been reported to be useful to distinguish between primary and metastatic lung adenocarcinoma. CK20 expression was significantly more prevalent in adenocarcinoma that originated in the GI tract than that of pulmonary or breast origin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB240Hu01 Recombinant Keratin 20 (KRT20) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB240Hu01 Polyclonal Antibody to Keratin 20 (KRT20) WB; IHC; ICC; IP.
MAB240Hu22 Monoclonal Antibody to Keratin 20 (KRT20) WB; IHC; ICC; IP.
Assay Kits SEB240Hu ELISA Kit for Keratin 20 (KRT20) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB240Mu01 Recombinant Keratin 20 (KRT20) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB240Mu01 Polyclonal Antibody to Keratin 20 (KRT20) WB; IHC; ICC; IP.
LAB240Mu71 Biotin-Linked Polyclonal Antibody to Keratin 20 (KRT20) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Keratin 20 (KRT20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 20 (KRT20) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB240Ra01 Recombinant Keratin 20 (KRT20) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB240Ra01 Polyclonal Antibody to Keratin 20 (KRT20) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Keratin 20 (KRT20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin 20 (KRT20) ELISA Kit Customized Service Offer
  1. "The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas."Differentiation 53:75-93(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker."J. Biol. Chem. 281:16453-16461(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Differential localization by in situ hybridization of distinct keratin mRNA species during intestinal epithelial cell development and differentiation."Differentiation 53:95-104(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns."J. Cell Biol. 111:567-580(1990) [PubMed] [Europe PMC] [Abstract]
  7. "An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium."Arch. Oral Biol. 45:879-887(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Keratin 20 helps maintain intermediate filament organization in intestinal epithelia."Mol. Biol. Cell 14:2959-2971(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]