Granzyme K (GZMK)

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GZM-K; TRYP2; PRSS; Serine Protease,Granzyme 3; Tryptase II; Fragmentin-3; Granzyme-3; NK-tryptase-2

Granzyme K (GZMK)

Granzyme K is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.Both the rat and the human equivalent gene TRYP2 shared considerable homology and common serine protease sequence features with human granzyme A . By fluorescence in situ hybridization, Baker et al. (1994) demonstrated that the TRYP2 gene, like HFSP, maps to 5q11-q12.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB209Hu01 Recombinant Granzyme K (GZMK) Positive Control; Immunogen; SDS-PAGE; WB.
APB209Hu01 Active Granzyme K (GZMK) Cell culture; Activity Assays.
Antibodies PAB209Hu01 Polyclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
MAB209Hu22 Monoclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
LAB209Hu71 Biotin-Linked Polyclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC.
LAB209Hu81 FITC-Linked Polyclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IF.
MAB209Hu21 Monoclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
Assay Kits SEB209Hu ELISA Kit for Granzyme K (GZMK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB209Mu01 Recombinant Granzyme K (GZMK) Positive Control; Immunogen; SDS-PAGE; WB.
RPB209Mu02 Recombinant Granzyme K (GZMK) Positive Control; Immunogen; SDS-PAGE; WB.
APB209Mu01 Active Granzyme K (GZMK) Cell culture; Activity Assays.
Antibodies PAB209Mu01 Polyclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
PAB209Mu02 Polyclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
MAB209Mu21 Monoclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
MAB209Mu25 Monoclonal Antibody to Granzyme K (GZMK) WB.
MAB209Mu22 Monoclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
MAB209Mu23 Monoclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
MAB209Mu24 Monoclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
MAB209Mu27 Monoclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
MAB209Mu29 Monoclonal Antibody to Granzyme K (GZMK) WB; IHC; ICC; IP.
Assay Kits SEB209Mu ELISA Kit for Granzyme K (GZMK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB209Ra01 Recombinant Granzyme K (GZMK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Granzyme K (GZMK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Granzyme K (GZMK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Granzyme K (GZMK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Granzyme K (GZMK) ELISA Kit Customized Service Offer
  1. "Cloning of cDNA for human granzyme 3."FEBS Lett. 364:268-271(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3."J. Leukoc. Biol. 59:763-768(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of three serine esterases isolated from human IL-2 activated killer cells."J. Immunol. 141:3142-3147(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions."J. Exp. Med. 176:1521-1529(1992) [PubMed] [Europe PMC] [Abstract]
  7. "The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features."J. Biol. Chem. 277:50923-50933(2002) [PubMed] [Europe PMC] [Abstract]