Interleukin 27 Receptor Alpha (IL27Ra)

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CRL1; IL27R; TCCR; WSX1; Zcytor1; T-Cell Cytokine Receptor Type 1; Cytokine receptor-like 1; Type I T-cell cytokine receptor

Interleukin 27 Receptor Alpha (IL27Ra)

Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor.In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.Sprecher et al. mapped the WSX1 gene to chromosome 19 by PCR analysis of a somatic cell hybrid panel.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB194Hu01 Recombinant Interleukin 27 Receptor Alpha (IL27Ra) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB194Hu01 Polyclonal Antibody to Interleukin 27 Receptor Alpha (IL27Ra) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 27 Receptor Alpha (IL27Ra) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 27 Receptor Alpha (IL27Ra) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB194Mu01 Recombinant Interleukin 27 Receptor Alpha (IL27Ra) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB194Mu01 Polyclonal Antibody to Interleukin 27 Receptor Alpha (IL27Ra) WB; IHC; ICC; IP.
Assay Kits SEB194Mu ELISA Kit for Interleukin 27 Receptor Alpha (IL27Ra) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB194Ra01 Recombinant Interleukin 27 Receptor Alpha (IL27Ra) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB194Ra01 Polyclonal Antibody to Interleukin 27 Receptor Alpha (IL27Ra) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Interleukin 27 Receptor Alpha (IL27Ra) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 27 Receptor Alpha (IL27Ra) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of a novel class I cytokine receptor."Biochem. Biophys. Res. Commun. 246:82-90(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Development of Th1-type immune responses requires the type I cytokine receptor TCCR."Nature 407:916-920(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27."J. Immunol. 172:2225-2231(2004) [PubMed] [Europe PMC] [Abstract]