Interleukin 31 (IL31)

Interleukin-31 (IL-31) is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. IL-31 is believed to play a role in inflammation of the skin.

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA  and OSMR that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB179Hu01 Recombinant Interleukin 31 (IL31) Positive Control; Immunogen; SDS-PAGE; WB.
APB179Hu01 Active Interleukin 31 (IL31) Cell culture; Activity Assays.
Antibodies PAB179Hu01 Polyclonal Antibody to Interleukin 31 (IL31) WB; IHC; ICC; IP.
MAB179Hu22 Monoclonal Antibody to Interleukin 31 (IL31) WB; IHC; ICC; IP.
Assay Kits SCB179Hu CLIA Kit for Interleukin 31 (IL31) Chemiluminescent immunoassay for Antigen Detection.
SEB179Hu ELISA Kit for Interleukin 31 (IL31) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB179Mu01 Recombinant Interleukin 31 (IL31) Positive Control; Immunogen; SDS-PAGE; WB.
RPB179Mu02 Recombinant Interleukin 31 (IL31) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB179Mu01 Polyclonal Antibody to Interleukin 31 (IL31) WB; IHC; ICC; IP.
PAB179Mu02 Polyclonal Antibody to Interleukin 31 (IL31) WB; IHC; ICC; IP.
Assay Kits SEB179Mu ELISA Kit for Interleukin 31 (IL31) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB179Mu CLIA Kit for Interleukin 31 (IL31) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB179Ra01 Recombinant Interleukin 31 (IL31) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB179Ra01 Polyclonal Antibody to Interleukin 31 (IL31) WB; IHC; ICC; IP.
LAB179Ra81 FITC-Linked Polyclonal Antibody to Interleukin 31 (IL31) WB; IHC; ICC; IF.
LAB179Ra71 Biotin-Linked Polyclonal Antibody to Interleukin 31 (IL31) WB; IHC; ICC.
MAB179Ra21 Monoclonal Antibody to Interleukin 31 (IL31) WB; IHC; ICC; IP.
Assay Kits SEB179Ra ELISA Kit for Interleukin 31 (IL31) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB179Ca01 Recombinant Interleukin 31 (IL31) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interleukin 31 (IL31) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 31 (IL31) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 31 (IL31) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 31 (IL31) ELISA Kit Customized Service Offer
  1. "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice." Nat. Immunol. 5:752-760(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis."J. Allergy Clin. Immunol. 117:418-425(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis."J. Allergy Clin. Immunol. 118:930-937(2006) [PubMed] [Europe PMC] [Abstract]