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Cluster Of Differentiation 1a (CD1a)

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CD1-A; CD1; FCB6; HTA1; R4; T6; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen

Cluster Of Differentiation 1a (CD1a)
CCC B175
HGNC 1634
PubMed 24362891
UniProt P06126
Wiki CD1A

CD1a (Cluster of Differentiation 1a)  is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells.

The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB175Hu01 Recombinant Cluster Of Differentiation 1a (CD1a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB175Hu01 Polyclonal Antibody to Cluster Of Differentiation 1a (CD1a) WB; IHC; ICC; IP.
MAB175Hu21 Monoclonal Antibody to Cluster Of Differentiation 1a (CD1a) WB; IHC; ICC; IP.
MAB175Hu22 Monoclonal Antibody to Cluster Of Differentiation 1a (CD1a) WB; IHC; ICC; IP.
MAB175Hu23 Monoclonal Antibody to Cluster Of Differentiation 1a (CD1a) WB
MAB175Hu24 Monoclonal Antibody to Cluster Of Differentiation 1a (CD1a) WB
MAB175Hu25 Monoclonal Antibody to Cluster Of Differentiation 1a (CD1a) WB
Assay Kits SEB175Hu ELISA Kit for Cluster Of Differentiation 1a (CD1a) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts."J. Immunol. 143:1723-1730(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c."Proc. Natl. Acad. Sci. U.S.A. 84:9189-9193(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Polymorphism of human CD1 genes."Tissue Antigens 54:122-127(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules."J. Invest. Dermatol. 92:628-631(1989) [PubMed] [Europe PMC] [Abstract]
  7. "A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6."Nature 323:540-543(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed] [Europe PMC] [Abstract]
  9. "CD1a molecules traffic through the early recycling endosomal pathway in human Langerhans cells."J. Invest. Dermatol. 116:401-408(2001) [PubMed] [Europe PMC] [Abstract]
  10. "CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens."J. Immunol. 175:6344-6351(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts."J. Immunol. 180:980-987(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A."Nat. Immunol. 4:808-815(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular mechanism of lipopeptide presentation by CD1a."Immunity 22:209-219(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Structural characterization of two CD1A allelic variants."Hum. Immunol. 62:1137-1141(2001) [PubMed] [Europe PMC] [Abstract]