≡

Cluster Of Differentiation 1e (CD1e)

[Edit]

CD1-E; CD1-A; R2G1; T-Cell Surface Glycoprotein CD1e,Membrane-Associated

Cluster Of Differentiation 1e (CD1e)
CCC B170
HGNC 1638
PubMed 15752135
UniProt P15812
Wiki httpCD1E

Cluster of differentiation 1e(CD1e),a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB170Hu01 Recombinant Cluster Of Differentiation 1e (CD1e) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB170Hu01 Polyclonal Antibody to Cluster Of Differentiation 1e (CD1e) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 1e (CD1e) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 1e (CD1e) ELISA Kit Customized Service Offer
  1. "Two classes of CD1 genes."Eur. J. Immunol. 19:285-292(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells."J. Biol. Chem. 275:37757-37764(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Polymorphism of human CD1 genes."Tissue Antigens 54:122-127(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Two novel CD1 E alleles identified in black African individuals."Tissue Antigens 59:417-420(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of two novel human CD1E alleles."Tissue Antigens 56:159-161(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens."Proc. Natl. Acad. Sci. U.S.A. 83:9154-9158(1986) [PubMed] [Europe PMC] [Abstract]
  9. "Assistance of microbial glycolipid antigen processing by CD1e."Science 310:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Control of the intracellular pathway of CD1e."Traffic 9:431-445(2008) [PubMed] [Europe PMC] [Abstract]
  11. "The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments."Biochem. J. 419:661-668(2009) [PubMed] [Europe PMC] [Abstract]
  12. "A naturally occurring mutation in CD1e impairs lipid antigen presentation."J. Immunol. 180:3642-3646(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of human CD1e reveals a groove suited for lipid-exchange processes."Proc. Natl. Acad. Sci. U.S.A. 108:13230-13235(2011) [PubMed] [Europe PMC] [Abstract]