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Integrin Alpha X (CD11c)

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ITGaX; CD11-C; ITG-AX; ITGA-X; Leu M5; Complement Component 3 Receptor 4 Subunit; CD11 antigen-like family member C; Leukocyte adhesion glycoprotein p150,95 alpha chain

Integrin Alpha X (CD11c)
CCC B159
HGNC 6152
MGI 96609
PubMed 9598326
RGD 1561123
UniProt P20702
Wiki ITGAX

CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.

CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB159Hu01 Recombinant Integrin Alpha X (CD11c) Positive Control; Immunogen; SDS-PAGE; WB.
EPB159Hu61 Eukaryotic Integrin Alpha X (CD11c) Positive Control; Immunogen; SDS-PAGE; WB.
APB159Hu61 Active Integrin Alpha X (CD11c) Cell culture; Activity Assays.
Antibodies PAB159Hu01 Polyclonal Antibody to Integrin Alpha X (CD11c) WB; IHC; ICC; IP.
MAB159Hu22 Monoclonal Antibody to Integrin Alpha X (CD11c) WB; IHC; ICC; IP.
MAB159Hu26 Monoclonal Antibody to Integrin Alpha X (CD11c) WB; IHC; ICC; IP.
MAB159Hu21 Monoclonal Antibody to Integrin Alpha X (CD11c) WB; IHC; ICC; IP.
MAB159Hu23 Monoclonal Antibody to Integrin Alpha X (CD11c) WB; IHC; ICC; IP.
Assay Kits SEB159Hu ELISA Kit for Integrin Alpha X (CD11c) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB159Mu01 Recombinant Integrin Alpha X (CD11c) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB159Mu01 Polyclonal Antibody to Integrin Alpha X (CD11c) WB; IHC; ICC; IP.
LAB159Mu71 Biotin-Linked Polyclonal Antibody to Integrin Alpha X (CD11c) WB; IHC; ICC.
Assay Kits SEB159Mu ELISA Kit for Integrin Alpha X (CD11c) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Alpha X (CD11c) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Alpha X (CD11c) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Alpha X (CD11c) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Alpha X (CD11c) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha X (CD11c) ELISA Kit Customized Service Offer
  1. "cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95."EMBO J. 6:4023-4028(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule."J. Biol. Chem. 265:2782-2788(1990) [PubMed] [Europe PMC] [Abstract]
  3. ErratumJ. Biol. Chem. 265:12750-12751(1990)
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins."J. Immunol. 138:2381-2383(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of an integrin with an alphaI domain, complement receptor type 4."EMBO J. 29:666-679(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Structure and binding interface of the cytosolic tails of alphaXbeta2 integrin."PLoS ONE 7:E41924-E41924(2012) [PubMed] [Europe PMC] [Abstract]
  9. "VPS35 mutations in Parkinson disease." Am. J. Hum. Genet. 89:162-167(2011) [PubMed] [Europe PMC] [Abstract]