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Fibrinogen Alpha Chain (FGA)

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Fib2; FG-A; FGA; Fibrinopeptide A

Fibrinogen Alpha Chain (FGA)
CCC B154
HGNC 3661
MGI 1316726
PubMed 12492584
RGD 2603
UniProt P02671
Wiki FGA

Fibrinogen alpha chain is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots.

In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB154Hu01 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB154Hu01 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; ICC; IHC-P; IHC-F; ELISA.
MAB154Hu22 Monoclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
LAB154Hu71 Biotin-Linked Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC.
LAB154Hu81 FITC-Linked Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IF.
Assay Kits SEB154Hu ELISA Kit for Fibrinogen Alpha Chain (FGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB154Mu01 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
RPB154Mu02 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB154Mu01 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
LAB154Mu71 Biotin-Linked Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC.
PAB154Mu02 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
Assay Kits SEB154Mu ELISA Kit for Fibrinogen Alpha Chain (FGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB154Ra01 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
RPB154Ra02 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB154Ra01 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
PAB154Ra02 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
LAB154Ra71 Biotin-Linked Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC.
LAB154Ra81 FITC-Linked Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IF.
MAB154Ra21 Monoclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
MAB154Ra22 Monoclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
Assay Kits SEB154Ra ELISA Kit for Fibrinogen Alpha Chain (FGA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fibrinogen Alpha Chain (FGA) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fibrinogen Alpha Chain (FGA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fibrinogen Alpha Chain (FGA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibrinogen Alpha Chain (FGA) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB154Bo01 Recombinant Fibrinogen Alpha Chain (FGA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB154Bo01 Polyclonal Antibody to Fibrinogen Alpha Chain (FGA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Fibrinogen Alpha Chain (FGA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fibrinogen Alpha Chain (FGA) ELISA Kit Customized Service Offer
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  30. "Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin."Nature 389:455-462(1997) [PubMed] [Europe PMC] [Abstract]
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  32. "Crystal structure of a recombinant alphaEC domain from human fibrinogen-420."Proc. Natl. Acad. Sci. U.S.A. 95:9099-9104(1998) [PubMed] [Europe PMC] [Abstract]
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  34. "Fibrinogen Kyoto II, a new congenitally abnormal molecule, characterized by the replacement of A alpha proline-18 by leucine."Blood 78:149-153(1991) [PubMed] [Europe PMC] [Abstract]
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  36. "An A alpha Ser-434 to N-glycosylated Asn substitution in a dysfibrinogen, fibrinogen Caracas II, characterized by impaired fibrin gel formation."J. Biol. Chem. 266:11575-11581(1991) [PubMed] [Europe PMC] [Abstract]
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  38. "Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain."Nat. Genet. 3:252-255(1993) [PubMed] [Europe PMC] [Abstract]
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  40. "Aberrant hepatic processing causes removal of activation peptide and primary polymerisation site from fibrinogen Canterbury (A-alpha 20 Val-to-Asp)."J. Clin. Invest. 96:2854-2858(1995) [PubMed] [Europe PMC] [Abstract]
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  42. ErratumNat. Genet. 23:373-373(1999)
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  44. "Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency."Thromb. Haemost. 113:567-576(2015) [PubMed] [Europe PMC] [Abstract]