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Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20)

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MS4A1; MS4-A1; B1; Bp35; LEU16; MS4-A2; S7; B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1

Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20)
CCC B148
HGNC 7315
MGI 88321
PubMed 22514692
RGD 1311999
UniProt P11836
Wiki CD20

Membrane-spanning 4-domains, subfamily A, member 1, also known as MS4A1, is a human gene.This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues.

This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB148Hu01 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) Positive Control; Immunogen; SDS-PAGE; WB.
EPB148Hu61 Eukaryotic Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB148Hu01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) WB; IHC; ICC; IP.
MAB148Hu21 Monoclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) WB; IHC; ICC; IP.
Assay Kits SEB148Hu ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB148Mu01 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) Positive Control; Immunogen; SDS-PAGE; WB.
RPB148Mu02 Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB148Mu01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) Recombinant Protein Customized Service Offer
Antibodies PAB148Ra01 Polyclonal Antibody to Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) ELISA Kit Customized Service Offer
  1. "Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein."J. Exp. Med. 167:1975-1980(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes."Proc. Natl. Acad. Sci. U.S.A. 85:208-212(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains."EMBO J. 7:711-717(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1)."J. Immunol. 142:2560-2568(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20."J. Immunol. 177:362-371(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  10. "CD20 deficiency in humans results in impaired T cell-independent antibody responses."J. Clin. Invest. 120:214-222(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23."PLoS ONE 7:E37187-E37187(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies."Blood 118:358-367(2011) [PubMed] [Europe PMC] [Abstract]