Coagulation Factor XIII A1 Polypeptide (F13A1)

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F13-A1; FXIIIA1; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain; Coagulation factor XIII A chain

Coagulation Factor XIII A1 Polypeptide (F13A1)

coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB094Hu01 Recombinant Coagulation Factor XIII A1 Polypeptide (F13A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB094Hu01 Polyclonal Antibody to Coagulation Factor XIII A1 Polypeptide (F13A1) WB,IHC,ICC/IF
MAB094Hu22 Monoclonal Antibody to Coagulation Factor XIII A1 Polypeptide (F13A1) WB; IHC; ICC; IP.
Assay Kits SEB094Hu ELISA Kit for Coagulation Factor XIII A1 Polypeptide (F13A1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB094Mu01 Recombinant Coagulation Factor XIII A1 Polypeptide (F13A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB094Mu01 Polyclonal Antibody to Coagulation Factor XIII A1 Polypeptide (F13A1) WB; IHC; ICC; IP.
Assay Kits SEB094Mu ELISA Kit for Coagulation Factor XIII A1 Polypeptide (F13A1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB094Ra01 Recombinant Coagulation Factor XIII A1 Polypeptide (F13A1) Positive Control; Immunogen; SDS-PAGE; WB.
RPB094Ra02 Recombinant Coagulation Factor XIII A1 Polypeptide (F13A1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB094Ra01 Polyclonal Antibody to Coagulation Factor XIII A1 Polypeptide (F13A1) WB; IHC; ICC; IP.
MAB094Ra21 Monoclonal Antibody to Coagulation Factor XIII A1 Polypeptide (F13A1) WB; IHC; ICC; IP.
Assay Kits SEB094Ra ELISA Kit for Coagulation Factor XIII A1 Polypeptide (F13A1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  15. "The Val34Leu polymorphism in the A subunit of coagulation factor XIII contributes to the large normal range in activity and demonstrates that the activation peptide plays a role in catalytic activity."Blood 92:2766-2770(1998) [PubMed] [Europe PMC] [Abstract]
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  17. ErratumNat. Genet. 23:373-373(1999)