Bone Sialoprotein (BSP)

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IBSP; Bsp; BspII; SpII; Integrin-Binding Bone Sialoprotein; Cell-binding sialoprotein; Bone sialoprotein 2

Bone Sialoprotein (BSP)

Bone sialoprotein (BSP) is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. BSP is a significant component of the bone extracellular matrix and has been suggested to constitute approximately 8% of all non-collagenous proteins found in bone and cementum. BSP was originally isolated from bovine cortical bone as a 23-kDa glycopeptide with high sialic acid content, as described in separate reports by Williams and Peacocke and Andrews and Herring Native BSP has an apparent molecular weight of 60-80 kDa based on SDS-PAGE, which is a considerable deviation from the predicted weight of approximately 33 kDa. The mammalian BSP cDNAs encode for proteins averaging 327 amino acids,, which includes the 16-residue preprotein secretory signal peptide.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB092Hu01 Recombinant Bone Sialoprotein (BSP) Positive Control; Immunogen; SDS-PAGE; WB.
EPB092Hu61 Eukaryotic Bone Sialoprotein (BSP) Positive Control; Immunogen; SDS-PAGE; WB.
EPB092Hu62 Eukaryotic Bone Sialoprotein (BSP) Positive Control; Immunogen; SDS-PAGE; WB.
APB092Hu61 Active Bone Sialoprotein (BSP) Cell culture; Activity Assays.
Antibodies PAB092Hu01 Polyclonal Antibody to Bone Sialoprotein (BSP) WB; IHC; ICC; IP.
MAB092Hu22 Monoclonal Antibody to Bone Sialoprotein (BSP) WB; IHC; ICC; IP.
Assay Kits SEB092Hu ELISA Kit for Bone Sialoprotein (BSP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB092Mu01 Recombinant Bone Sialoprotein (BSP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB092Mu02 Recombinant Bone Sialoprotein (BSP) Positive Control; Immunogen; SDS-PAGE; WB.
EPB092Mu61 Eukaryotic Bone Sialoprotein (BSP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB092Mu01 Polyclonal Antibody to Bone Sialoprotein (BSP) WB; IHC; ICC; IP.
PAB092Mu02 Polyclonal Antibody to Bone Sialoprotein (BSP) WB; IHC; ICC; IP.
Assay Kits SEB092Mu ELISA Kit for Bone Sialoprotein (BSP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bone Sialoprotein (BSP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bone Sialoprotein (BSP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bone Sialoprotein (BSP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bone Sialoprotein (BSP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bone Sialoprotein (BSP) ELISA Kit Customized Service Offer
  1. "Human bone sialoprotein. Deduced protein sequence and chromosomal localization."J. Biol. Chem. 265:2347-2351(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The human bone sialoprotein gene (IBSP): genomic localization and characterization."Genomics 17:408-415(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence."Matrix Biol. 14:31-40(1994) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone."J. Biol. Chem. 262:9702-9708(1987) [PubMed] [Europe PMC] [Abstract]
  6. "Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding."J. Biol. Chem. 276:36839-36848(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Posttranslational modifications to human bone sialoprotein determined by mass spectrometry."Biochemistry 40:12983-12991(2001) [PubMed] [Europe PMC] [Abstract]