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Alkaline Phosphatase, Tissue-nonspecific (ALPL)

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BALP; BSAP; HOPS; AP-TNAP; TNSALP; Bone Alkaline Phosphatase; Alkaline Phosphatase,Tissue-Nonspecific Isozyme; Alkaline Phosphatase, Liver/Bone/Kidney

Alkaline Phosphatase, Tissue-nonspecific (ALPL)
CCC B091
HGNC 438
MGI 87983
PubMed 3174660
RGD 2100
UniProt P05186
Wiki ALPL

Alkaline phosphatase, tissue-nonspecific isozyme is an enzyme encoded by the ALPL gene.There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB091Hu01 Recombinant Alkaline Phosphatase, Tissue-nonspecific (ALPL) Positive Control; Immunogen; SDS-PAGE; WB.
APB091Hu61 Active Alkaline Phosphatase, Tissue-nonspecific (ALPL) Cell culture; Activity Assays.
EPB091Hu61 Eukaryotic Alkaline Phosphatase, Tissue-nonspecific (ALPL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB091Hu01 Polyclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB; IHC; ICC; IP.
MAB091Hu22 Monoclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB,IHC
MAB091Hu21 Monoclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB; IHC; ICC; IP.
MAB091Hu23 Monoclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB; IHC; ICC; IP.
Assay Kits SEB091Hu ELISA Kit for Alkaline Phosphatase, Tissue-nonspecific (ALPL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB091Mu01 Recombinant Alkaline Phosphatase, Tissue-nonspecific (ALPL) Positive Control; Immunogen; SDS-PAGE; WB.
RPB091Mu02 Recombinant Alkaline Phosphatase, Tissue-nonspecific (ALPL) Positive Control; Immunogen; SDS-PAGE; WB.
EPB091Mu61 Eukaryotic Alkaline Phosphatase, Tissue-nonspecific (ALPL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB091Mu01 Polyclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB; IHC; ICC; IP.
LAB091Mu71 Biotin-Linked Polyclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB; IHC; ICC.
LAB091Mu81 FITC-Linked Polyclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB; IHC; ICC; IF.
PAB091Mu02 Polyclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB; IHC; ICC; IP.
Assay Kits SEB091Mu ELISA Kit for Alkaline Phosphatase, Tissue-nonspecific (ALPL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB091Ra01 Recombinant Alkaline Phosphatase, Tissue-nonspecific (ALPL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB091Ra01 Polyclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB; IHC; ICC; IP.
MAB091Ra21 Monoclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB; IHC; ICC; IP.
Assay Kits SEB091Ra ELISA Kit for Alkaline Phosphatase, Tissue-nonspecific (ALPL) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB091Ra CLIA Kit for Alkaline Phosphatase, Tissue-nonspecific (ALPL) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Alkaline Phosphatase, Tissue-nonspecific (ALPL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) Polyclonal Antibody Customized Service Offer
Assay Kits SEB091Rb ELISA Kit for Alkaline Phosphatase, Tissue-nonspecific (ALPL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB091Bo01 Recombinant Alkaline Phosphatase, Tissue-nonspecific (ALPL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB091Bo01 Polyclonal Antibody to Alkaline Phosphatase, Tissue-nonspecific (ALPL) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alkaline Phosphatase, Tissue-nonspecific (ALPL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alkaline Phosphatase, Tissue-nonspecific (ALPL) ELISA Kit Customized Service Offer
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  16. "A homoallelic Gly317-->Asp mutation in ALPL causes the perinatal (lethal) form of hypophosphatasia in Canadian mennonites."Genomics 17:215-217(1993) [PubMed] [Europe PMC] [Abstract]
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  18. "Identification of novel missense mutations (Phe310Leu and Gly439Arg) in a neonatal case of hypophosphatasia."J. Clin. Endocrinol. Metab. 81:4458-4461(1996) [PubMed] [Europe PMC] [Abstract]
  19. "Identification of fifteen novel mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in European patients with severe hypophosphatasia."Eur. J. Hum. Genet. 6:308-314(1998) [PubMed] [Europe PMC] [Abstract]
  20. "Hypophosphatasia: identification of five novel missense mutations (G507A, G705A, A748G, T1155C, G1320A) in the tissue-nonspecific alkaline phosphatase gene among Japanese patients."Hum. Mutat. Suppl. 1:S263-S267(1998) [PubMed] [Europe PMC] [Abstract]
  21. "Correlations of genotype and phenotype in hypophosphatasia."Hum. Mol. Genet. 8:1039-1046(1999) [PubMed] [Europe PMC] [Abstract]
  22. "Characterization of eleven novel mutations (M45L, R119H, 544delG, G145V, H154Y, C184Y, D289V, 862+5A, 1172delC, R411X, E459K) in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in patients with severe hypophosphatasia."Hum. Mutat. 13:171-172(1999) [PubMed] [Europe PMC] [Abstract]
  23. "Severe hypercalcaemia and respiratory insufficiency associated with infantile hypophosphatasia caused by two novel mutations of the tissue-nonspecific alkaline phosphatase gene."Eur. J. Pediatr. 159:375-379(2000) [PubMed] [Europe PMC] [Abstract]
  24. "Fifteen new mutations (-195C>T, L-12X, 298-2A>G, T117N, A159T, R229S, 997+2T>A, E274X, A331T, H364R, D389G, 1256delC, R433H, N461I, C472S) in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in patients with hypophosphatasia." Hum. Mutat. 15:293-293(2000) [PubMed] [Europe PMC] [Abstract]
  25. "Asp361Val mutant of alkaline phosphatase found in patients with dominantly inherited hypophosphatasia inhibits the activity of the wild-type enzyme."J. Clin. Endocrinol. Metab. 85:743-747(2000) [PubMed] [Europe PMC] [Abstract]
  26. "Perinatal hypophosphatasia: radiology, pathology and molecular biology studies in a family harboring a splicing mutation (648+1A) and a novel missense mutation (N400S) in the tissue-nonspecific alkaline phosphatase (TNSALP) gene."Am. J. Med. Genet. 103:235-240(2001) [PubMed] [Europe PMC] [Abstract]
  27. "A molecular approach to dominance in hypophosphatasia."Hum. Genet. 109:99-108(2001) [PubMed] [Europe PMC] [Abstract]
  28. "Twelve novel mutations in the tissue-nonspecific alkaline phosphatase gene (ALPL) in patients with various forms of hypophosphatasia."Hum. Mutat. 18:83-84(2001) [PubMed] [Europe PMC] [Abstract]
  29. "Mutational analysis and functional correlation with phenotype in German patients with childhood-type hypophosphatasia."J. Bone Miner. Res. 16:2313-2319(2001) [PubMed] [Europe PMC] [Abstract]
  30. "A novel point mutation (C571T) in the tissue-non-specific alkaline phosphatase gene in a case of adult-type hypophosphatasia."Oral Dis. 7:331-335(2001) [PubMed] [Europe PMC] [Abstract]
  31. "Glu274Lys/Gly309Arg mutation of the tissue-nonspecific alkaline phosphatase gene in neonatal hypophosphatasia associated with convulsions."J. Inherit. Metab. Dis. 25:35-40(2002) [PubMed] [Europe PMC] [Abstract]
  32. "Denaturing gradient gel electrophoresis analysis of the tissue nonspecific alkaline phosphatase isoenzyme gene in hypophosphatasia."Mol. Genet. Metab. 75:143-153(2002) [PubMed] [Europe PMC] [Abstract]
  33. "Severe hypophosphatasia: characterization of fifteen novel mutations in the ALPL gene."Hum. Mutat. 22:105-106(2003) [PubMed] [Europe PMC] [Abstract]
  34. "Molecular study of three cases of odontohypophosphatasia resulting from heterozygosity for mutations in the tissue non-specific alkaline phosphatase gene."J. Med. Genet. 40:605-609(2003) [PubMed] [Europe PMC] [Abstract]
  35. "Childhood hypophosphatasia: a case report due to a novel mutation."Arch. Pediatr. 11:440-443(2004) [PubMed] [Europe PMC] [Abstract]
  36. "Characterization of 11 novel mutations in the tissue non-specific alkaline phosphatase gene responsible for hypophosphatasia and genotype-phenotype correlations."Mol. Genet. Metab. 84:273-277(2005) [PubMed] [Europe PMC] [Abstract]