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Glutathione S Transferase Pi (GSTp)

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GSTP1; GST-P1; DFN7; FAEES3; GST3

Glutathione S Transferase Pi (GSTp)
CCC B090
HGNC 4638
MGI 95864
PubMed 9744547
UniProt P09211
Wiki GSTP1

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.The predicted 209-amino acid protein shares 86% sequence identity with GSTP. However, GST-pi has a pI of 5.5, while that of GSTP is 6.9. Northern hybridization revealed that GST-pi is expressed as a 750-nucleotide mRNA in liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB090Hu01 Recombinant Glutathione S Transferase Pi (GSTp) Positive Control; Immunogen; SDS-PAGE; WB.
APB090Hu01 Active Glutathione S Transferase Pi (GSTp) Cell culture; Activity Assays.
RPB090Hu02 Recombinant Glutathione S Transferase Pi (GSTp) Positive Control; Immunogen; SDS-PAGE; WB.
APB090Hu02 Active Glutathione S Transferase Pi (GSTp) Cell culture; Activity Assays.
Antibodies PAB090Hu01 Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC/IF
MAB090Hu22 Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
LAB090Hu71 Biotin-Linked Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC.
LAB090Hu81 FITC-Linked Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IF.
LAB090Hu72 Biotin-Linked Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC.
LAB090Hu82 FITC-Linked Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IF.
MAB090Hu21 Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
PAB090Hu02 Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
MAB090Hu23 Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
MAB090Hu24 Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
MAB090Hu25 Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
Assay Kits SEB090Hu ELISA Kit for Glutathione S Transferase Pi (GSTp) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB090Mu01 Recombinant Glutathione S Transferase Pi (GSTp) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB090Mu01 Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
LAB090Mu71 Biotin-Linked Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC.
LAB090Mu81 FITC-Linked Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Glutathione S Transferase Pi (GSTp) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Pi (GSTp) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB090Ra01 Recombinant Glutathione S Transferase Pi (GSTp) Positive Control; Immunogen; SDS-PAGE; WB.
APB090Ra01 Active Glutathione S Transferase Pi (GSTp) Cell culture; Activity Assays.
Antibodies PAB090Ra01 Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
LAB090Ra71 Biotin-Linked Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC.
Assay Kits SEB090Ra ELISA Kit for Glutathione S Transferase Pi (GSTp) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Hamster (Chinese hamster)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB090Ha01 Recombinant Glutathione S Transferase Pi (GSTp) Positive Control; Immunogen; SDS-PAGE; WB.
APB090Ha01 Active Glutathione S Transferase Pi (GSTp) Cell culture; Activity Assays.
Antibodies PAB090Ha01 Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
MAB090Ha21 Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB.
MAB090Ha22 Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
MAB090Ha23 Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glutathione S Transferase Pi (GSTp) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Pi (GSTp) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB090Po01 Recombinant Glutathione S Transferase Pi (GSTp) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB090Po01 Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
MAB090Po21 Monoclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
Assay Kits SEB090Po ELISA Kit for Glutathione S Transferase Pi (GSTp) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB090Bo01 Recombinant Glutathione S Transferase Pi (GSTp) Positive Control; Immunogen; SDS-PAGE; WB.
APB090Bo01 Active Glutathione S Transferase Pi (GSTp) Cell culture; Activity Assays.
Antibodies PAB090Bo01 Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IP.
LAB090Bo71 Biotin-Linked Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC.
LAB090Bo81 FITC-Linked Polyclonal Antibody to Glutathione S Transferase Pi (GSTp) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Glutathione S Transferase Pi (GSTp) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glutathione S Transferase Pi (GSTp) ELISA Kit Customized Service Offer
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  11. , Submitted (DEC-2008) to UniProtKB
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  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity."J. Neurochem. 118:902-914(2011) [PubMed] [Europe PMC] [Abstract]
  22. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  23. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  25. "The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate."Biochemistry 36:576-585(1997) [PubMed] [Europe PMC] [Abstract]
  26. "Structure and function of the xenobiotic substrate-binding site and location of a potential non-substrate-binding site in a class pi glutathione S-transferase."Biochemistry 36:9690-9702(1997) [PubMed] [Europe PMC] [Abstract]
  27. "The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution."J. Mol. Biol. 274:84-100(1997) [PubMed] [Europe PMC] [Abstract]
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  29. "Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1."Biochemistry 38:10231-10238(1999) [PubMed] [Europe PMC] [Abstract]
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  31. "Rational design of an organometallic glutathione transferase inhibitor."Angew. Chem. Int. Ed. 48:3854-3857(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases."Cancer Res. 69:8025-8034(2009) [PubMed] [Europe PMC] [Abstract]