Tryptase (TPS)
[Edit]TPSAB1; Tryptase Alpha/Beta 1; Tryptase Alpha II; Tryptase Beta I; Tryptase-I; Tryptase-II; Tryptase-III
-91070.jpg)
Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells that has recently been used as a marker for mast cell activation. It is involved with allergenic response and is suspected to act as a mitogen for fibroblast lines. Elevated levels of serum tryptase occur in both anaphylactic and anaphylactoid reactions, but a negative test does not exclude anaphylaxis.
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB070Hu01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB070Hu02 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APB070Hu02 | Active Tryptase (TPS) | Cell culture; Activity Assays. | |
| Antibodies | PAB070Hu01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| MAB070Hu22 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC | |
| LAB070Hu71 | Biotin-Linked Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC. | |
| MAB070Hu24 | Monoclonal Antibody to Tryptase (TPS) | WB,IHC | |
| MAB070Hu26 | Monoclonal Antibody to Tryptase (TPS) | WB,IHC | |
| LAB070Hu76 | Biotin-Linked Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC. | |
| MAB070Hu21 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. | |
| MAB070Hu23 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC. | |
| Assay Kits | SEB070Hu | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB070Hu | CLIA Kit for Tryptase (TPS) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB070Mu01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB070Mu02 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB070Mu01 | Polyclonal Antibody to Tryptase (TPS) | WB |
| LAB070Mu71 | Biotin-Linked Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC. | |
| PAB070Mu02 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB070Mu | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB070Ra01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB070Ra02 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPB070Ra03 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB070Ra01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| PAB070Ra02 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. | |
| LAB070Ra71 | Biotin-Linked Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC. | |
| PAB070Ra03 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB070Ra | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB070Ca01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB070Ca02 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB070Ca01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC |
| LAB070Ca71 | Biotin-Linked Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC. | |
| MAB070Ca21 | Monoclonal Antibody to Tryptase (TPS) | WB. | |
| PAB070Ca02 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. | |
| PAB070Ca03 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB070Ca | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| HEB070Ca | High Sensitive ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB070Po01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB070Po02 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB070Po01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| MAB070Po21 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. | |
| PAB070Po02 | Polyclonal Antibody to Tryptase (TPS) | IHC | |
| Assay Kits | SEB070Po | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB070Eq01 | Recombinant Tryptase (TPS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB070Eq01 | Polyclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. |
| MAB070Eq21 | Monoclonal Antibody to Tryptase (TPS) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB070Eq | ELISA Kit for Tryptase (TPS) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Cloning and characterization of complementary DNA for human tryptase."J. Clin. Invest. 84:1188-1195(1989) [PubMed] [Europe PMC] [Abstract]
- "Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family."Proc. Natl. Acad. Sci. U.S.A. 87:3811-3815(1990) [PubMed] [Europe PMC] [Abstract]
- "Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3."J. Biol. Chem. 274:3355-3362(1999) [PubMed] [Europe PMC] [Abstract]
- "Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations."J. Allergy Clin. Immunol. 124:1099-1105(2009) [PubMed] [Europe PMC] [Abstract]
- "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates."J. Biol. Chem. 262:1363-1373(1987) [PubMed] [Europe PMC] [Abstract]
- "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."Blood 103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]
- "Active monomers of human beta-tryptase have expanded substrate specificities."Int. Immunopharmacol. 7:1900-1908(2007) [PubMed] [Europe PMC] [Abstract]
- "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
- "The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region."J. Mol. Biol. 321:491-502(2002) [PubMed] [Europe PMC] [Abstract]
- "Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog."Pharmacogenetics 10:389-396(2000) [PubMed] [Europe PMC] [Abstract]