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Apoptosis Inducing Factor (AIF)

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PDCD8; Programmed Cell Death protein 8; Apoptosis-inducing factor 1, mitochondrial

Apoptosis Inducing Factor (AIF)
CCC B064
HGNC 8768
MGI 1349419
PubMed 12022952
RGD 620817
UniProt O95831
Wiki AIF

Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis (positive intrinsic regulator of apoptosis) by causing DNA fragmentation and chromatin condensation. It also acts as an NADH oxidase. Another AIF function is to regulate the permeability of the mitochondrial membrane upon apoptosis.

Normally it is found behind the outer membrane of the mitochondria and is therefore secluded from the nucleus. However, when the mitochondria is damaged, it moves to the cytosol and to the nucleus.

Inactivation of AIF leads to resistance of embryonic stem cells to death following the withdrawal of growth factors indicating that it is involved in apoptosis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB064Hu01 Recombinant Apoptosis Inducing Factor (AIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB064Hu01 Polyclonal Antibody to Apoptosis Inducing Factor (AIF) WB,IHC,ICC/IF
MAB064Hu22 Monoclonal Antibody to Apoptosis Inducing Factor (AIF) WB; IHC; ICC; IP.
Assay Kits SEB064Hu ELISA Kit for Apoptosis Inducing Factor (AIF) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB064Hu CLIA Kit for Apoptosis Inducing Factor (AIF) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apoptosis Inducing Factor (AIF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apoptosis Inducing Factor (AIF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apoptosis Inducing Factor (AIF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apoptosis Inducing Factor (AIF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apoptosis Inducing Factor (AIF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB064Ra01 Recombinant Apoptosis Inducing Factor (AIF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB064Ra01 Polyclonal Antibody to Apoptosis Inducing Factor (AIF) WB; IHC; ICC; IP.
MAB064Ra21 Monoclonal Antibody to Apoptosis Inducing Factor (AIF) WB; IHC; ICC; IP.
Assay Kits SEB064Ra ELISA Kit for Apoptosis Inducing Factor (AIF) Enzyme-linked immunosorbent assay for Antigen Detection.
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  2. "AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer."J. Biol. Chem. 281:6413-6427(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with NADH oxidase activity."J. Biol. Chem. 281:18507-18518(2006) [PubMed] [Europe PMC] [Abstract]
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  8. "Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis."FEBS Lett. 476:118-123(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g)."FEBS Lett. 580:6375-6383(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP."Mol. Cell. Biol. 28:237-247(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Apoptosis-inducing factor plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells."Apoptosis 14:796-808(2009) [PubMed] [Europe PMC] [Abstract]
  14. "A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2." Cell Death Differ. 17:1155-1166(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Vital function of PRELI and essential requirement of its LEA motif."Cell Death Dis. 1:E21-E21(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation."Biochemistry 50:11084-11096(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "DNA binding is required for the apoptogenic action of apoptosis inducing factor."Nat. Struct. Biol. 9:680-684(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Cowchock syndrome is associated with a mutation in apoptosis-inducing factor."Am. J. Hum. Genet. 91:1095-1102(2012) [PubMed] [Europe PMC] [Abstract]
  21. "Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor."Am. J. Hum. Genet. 86:639-649(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Early prenatal ventriculomegaly due to an AIFM1 mutation identified by linkage analysis and whole exome sequencing."Mol. Genet. Metab. 104:517-520(2011) [PubMed] [Europe PMC] [Abstract]
  23. "From ventriculomegaly to severe muscular atrophy: Expansion of the clinical spectrum related to mutations in AIFM1."Mitochondrion 21C:12-18(2015) [PubMed] [Europe PMC] [Abstract]