Heat Shock 70kDa Protein 1 Like Protein (HSPA1L)

[Edit]

HSP-A1L; HSPA1-L; HSP70-HOM; Hum70t

Heat Shock 70kDa Protein 1 Like Protein (HSPA1L)

Heat shock 70 kDa protein 1L is a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein.The HSPA1L rs2075800 G allele frequency was higher in the sarcoid-uveitis group than in both the sarcoid-nonuveitis and control groups (83% vs 71%, OR, 2.00, P(c) = 0.01; and 83% vs 66%, OR, 2.45, P(c) = 0.00005, respectively). Similar results were observed when considering the carriage frequency of the associated haplotype (HSP70 haplotype 2) across the 3 study groups.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB062Hu01 Recombinant Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Positive Control; Immunogen; SDS-PAGE; WB.
RPB062Hu02 Recombinant Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB062Hu01 Polyclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB; IHC; ICC; IP.
MAB062Hu22 Monoclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB,IHC,ICC/IF
PAB062Hu02 Polyclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB; IHC; ICC; IP.
LAB062Hu71 Biotin-Linked Polyclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB; IHC; ICC.
LAB062Hu81 FITC-Linked Polyclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB; IHC; ICC; IF.
LAB062Hu72 Biotin-Linked Monoclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB; IHC; ICC.
MAB062Hu21 Monoclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB; IHC; ICC; IP.
MAB062Hu23 Monoclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB; IHC; ICC; IP.
Assay Kits SEB062Mi ELISA Kit for Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB062Hu ELISA Kit for Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Polyclonal Antibody Customized Service Offer
Assay Kits SEB062Mi ELISA Kit for Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB062Mu ELISA Kit for Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB062Ra01 Recombinant Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB062Ra01 Polyclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB; IHC; ICC; IP.
LAB062Ra71 Biotin-Linked Polyclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB; IHC; ICC.
MAB062Ra22 Monoclonal Antibody to Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) WB; IHC; ICC; IP.
Assay Kits SEB062Mi ELISA Kit for Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB062Ra ELISA Kit for Heat Shock 70kDa Protein 1 Like Protein (HSPA1L) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Structure and expression of the three MHC-linked HSP70 genes."Immunogenetics 32:242-251(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic structure of the spermatid-specific HSP70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man."J. Biochem. 124:347-353(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy."Nature 504:291-295(2013) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78."PLoS ONE 5:E8625-E8625(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Polymorphic analysis of the three MHC-linked HSP70 genes."Immunogenetics 36:357-362(1992) [PubMed] [Europe PMC] [Abstract]