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Protein Kinase C Beta 1 (PKCb1)

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PKC-B1; PRKCB; PRKCB1

Protein Kinase C Beta 1 (PKCb1)
CCC B045
HGNC 9395
MGI 97596
PubMed 8732668
RGD 3396
UniProt P05771
Wiki PRKCB1

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.

  • Protein Kinase C Beta 1 is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB045Hu01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB045Hu01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
MAB045Hu22 Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
Assay Kits SEB045Hu ELISA Kit for Protein Kinase C Beta 1 (PKCb1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase C Beta 1 (PKCb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase C Beta 1 (PKCb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase C Beta 1 (PKCb1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB045Ra01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB045Ra01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
LAB045Ra71 Biotin-Linked Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC.
LAB045Ra81 FITC-Linked Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IF.
MAB045Ra21 Monoclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
Assay Kits SEB045Ra ELISA Kit for Protein Kinase C Beta 1 (PKCb1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB045Rb01 Recombinant Protein Kinase C Beta 1 (PKCb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB045Rb51 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
LAB045Rb71 Biotin-Linked Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC.
PAB045Rb01 Polyclonal Antibody to Protein Kinase C Beta 1 (PKCb1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Kinase C Beta 1 (PKCb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase C Beta 1 (PKCb1) ELISA Kit Customized Service Offer
  1. "Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways."Science 233:859-866(1986) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structures of human protein kinase C beta I and beta II differ only in their C-terminal sequences."FEBS Lett. 223:138-142(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells."DNA Cell Biol. 14:213-222(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Positive and negative regulation of the transcription of the human protein kinase C beta gene."J. Biol. Chem. 267:6158-6163(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters."J. Biol. Chem. 267:20804-20810(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Alternative splicing increases the diversity of the human protein kinase C family."DNA 6:389-394(1987) [PubMed] [Europe PMC] [Abstract]
  10. "Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta-I/beta-II."Nucleic Acids Res. 15:7179-7180(1987) [PubMed] [Europe PMC] [Abstract]
  11. "PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization."EMBO J. 20:5692-5702(2001) [PubMed] [Europe PMC] [Abstract]
  12. "The protein kinase Cbeta-selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts."Cancer Res. 65:7462-7469(2005) [PubMed] [Europe PMC] [Abstract]
  13. "The phosphatase PHLPP controls the cellular levels of protein kinase C."J. Biol. Chem. 283:6300-6311(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription."J. Biol. Chem. 284:8567-8581(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4."Nature 464:792-796(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Protein kinase C beta (PKC beta): normal functions and diseases."J. Biochem. 132:677-682(2002) [PubMed] [Europe PMC] [Abstract]
  19. "Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications."Rev. Endocr. Metab. Disord. 11:61-74(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor."Biochemistry 45:13970-13981(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]