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Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7)

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CD27; S152; T14; Tp55; CD27L receptor;

Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7)
CCC B043
HGNC 11922
MGI 88326
PubMed 16916327
RGD 1560499
UniProt P26842
Wiki CD27

CD27 is a tumor necrosis factor receptor. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor.

CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB043Hu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Positive Control; Immunogen; SDS-PAGE; WB.
APB043Hu01 Active Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Cell culture; Activity Assays.
Antibodies PAB043Hu01 Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) WB; IHC; ICC; IP.
LAB043Hu71 Biotin-Linked Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) WB; IHC; ICC.
MAB043Hu21 Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) WB; IHC; ICC; IP.
Assay Kits SEB043Hu ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB043Mu01 Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 7 (TNFRSF7) ELISA Kit Customized Service Offer
  1. "The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family."J. Immunol. 147:3165-3169(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and chromosomal localization of the human CD27 gene."J. Immunol. 149:3937-3943(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2."Eur. J. Immunol. 28:2208-2216(1998) [PubMed] [Europe PMC] [Abstract]
  8. "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein."Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) [PubMed] [Europe PMC] [Abstract]
  9. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  10. "CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia."J. Allergy Clin. Immunol. 129:787-793(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27."Haematologica 98:473-478(2013) [PubMed] [Europe PMC] [Abstract]