Integrin Beta 1 (ITGb1)
[Edit]CD29; MSK12; ITG-B1; FNRB; GPIIA; MDF2; MSK12; VLAB; Fibronectin Receptor Beta Polypeptide; Antigen CD29 Includes MDF2; Glycoprotein IIa; VLA-4 subunit beta
Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), also known as ITGB1 or CD29, is a human gene. CD29 is an integrin unit associated with very late antigen receptors. Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB042Hu01 | Recombinant Integrin Beta 1 (ITGb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPB042Hu02 | Recombinant Integrin Beta 1 (ITGb1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAB042Hu01 | Polyclonal Antibody to Integrin Beta 1 (ITGb1) | WB; IHC; ICC; IP. |
MAB042Hu22 | Monoclonal Antibody to Integrin Beta 1 (ITGb1) | WB; IHC; ICC; IP. | |
PAB042Hu02 | Polyclonal Antibody to Integrin Beta 1 (ITGb1) | WB; IHC; ICC; IP. | |
LAB042Hu71 | Biotin-Linked Polyclonal Antibody to Integrin Beta 1 (ITGb1) | WB; IHC; ICC. | |
MAB042Hu21 | Monoclonal Antibody to Integrin Beta 1 (ITGb1) | WB; IHC; ICC; IP. | |
Assay Kits | SEB042Hu | ELISA Kit for Integrin Beta 1 (ITGb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
IEB042Hu | Instant ELISA Kit for Integrin Beta 1 (ITGb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB042Mu01 | Recombinant Integrin Beta 1 (ITGb1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB042Mu01 | Polyclonal Antibody to Integrin Beta 1 (ITGb1) | WB; IHC; ICC; IP. |
Assay Kits | SEB042Mu | ELISA Kit for Integrin Beta 1 (ITGb1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Integrin Beta 1 (ITGb1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Integrin Beta 1 (ITGb1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Integrin Beta 1 (ITGb1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Integrin Beta 1 (ITGb1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Integrin Beta 1 (ITGb1) | ELISA Kit Customized Service Offer |
- "Amino acid sequence of the human fibronectin receptor."J. Cell Biol. 105:1183-1190(1987) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit."J. Cell Biol. 121:171-178(1993) [PubMed] [Europe PMC] [Abstract]
- "Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility."J. Cell Biol. 127:557-565(1994) [PubMed] [Europe PMC] [Abstract]
- "A human integrin beta 1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing."Gene 95:261-266(1990) [PubMed] [Europe PMC] [Abstract]
- "An alternative form of the integrin beta 1 subunit with a variant cytoplasmic domain."J. Biol. Chem. 267:7116-7120(1992) [PubMed] [Europe PMC] [Abstract]
- "Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle."Biochem. Biophys. Res. Commun. 214:279-285(1995) [PubMed] [Europe PMC] [Abstract]
- "A novel beta 1 integrin isoform produced by alternative splicing: unique expression in cardiac and skeletal muscle."FEBS Lett. 369:340-344(1995) [PubMed] [Europe PMC] [Abstract]
- "Identification of beta1C-2, a novel variant of the integrin beta1 subunit generated by utilization of an alternative splice acceptor site in exon C."Biochem. J. 330:1255-1263(1998) [PubMed] [Europe PMC] [Abstract]
- "Interaction of ACE2 and integrin beta1 in failing human heart."Biochim. Biophys. Acta 1689:175-178(2004) [PubMed] [Europe PMC] [Abstract]
- "Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2."J. Virol. 67:6847-6852(1993) [PubMed] [Europe PMC] [Abstract]
- "Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells."J. Cell Biol. 132:211-226(1996) [PubMed] [Europe PMC] [Abstract]
- "Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin."EMBO J. 17:1606-1613(1998) [PubMed] [Europe PMC] [Abstract]
- "The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor."Blood 94:663-672(1999) [PubMed] [Europe PMC] [Abstract]
- "A novel protease-docking function of integrin at invadopodia."J. Biol. Chem. 274:24947-24952(1999) [PubMed] [Europe PMC] [Abstract]
- "A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation."J. Cell Biol. 147:1391-1398(1999) [PubMed] [Europe PMC] [Abstract]
- "Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation."Hum. Mol. Genet. 10:2953-2960(2001) [PubMed] [Europe PMC] [Abstract]
- "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement."J. Biol. Chem. 277:20895-20902(2002) [PubMed] [Europe PMC] [Abstract]
- "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."J. Cell Biol. 156:361-376(2002) [PubMed] [Europe PMC] [Abstract]
- "The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading."J. Cell Biol. 156:377-387(2002) [PubMed] [Europe PMC] [Abstract]
- "Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha."J. Biol. Chem. 278:6567-6574(2003) [PubMed] [Europe PMC] [Abstract]
- "RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1."J. Biol. Chem. 279:13027-13034(2004) [PubMed] [Europe PMC] [Abstract]
- "NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."Mol. Biol. Cell 15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]
- "Myosin-X provides a motor-based link between integrins and the cytoskeleton."Nat. Cell Biol. 6:523-531(2004) [PubMed] [Europe PMC] [Abstract]
- "Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration."Dev. Cell 9:663-673(2005) [PubMed] [Europe PMC] [Abstract]
- "The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins."J. Cell Sci. 118:3739-3749(2005) [PubMed] [Europe PMC] [Abstract]
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
- "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
- "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
- "Interaction of integrin beta1 with cytokeratin 1 in neuroblastoma NMB7 cells."Biochem. Soc. Trans. 35:1292-1294(2007) [PubMed] [Europe PMC] [Abstract]
- "Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments."Dev. Cell 13:496-510(2007) [PubMed] [Europe PMC] [Abstract]
- "Integrin trafficking regulated by Rab21 is necessary for cytokinesis."Dev. Cell 15:371-385(2008) [PubMed] [Europe PMC] [Abstract]
- "JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation."J. Cell Biol. 183:1159-1173(2008) [PubMed] [Europe PMC] [Abstract]
- "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
- "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
- "The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry."J. Virol. 84:10026-10037(2010) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration."J. Biol. Chem. 286:43735-43747(2011) [PubMed] [Europe PMC] [Abstract]
- "Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition."J. Cell Biol. 194:307-322(2011) [PubMed] [Europe PMC] [Abstract]
- "Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins."J. Cell Sci. 124:879-891(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Mechanistic insights into regulated cargo binding by ACAP1 protein."J. Biol. Chem. 287:28675-28685(2012) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor."J. Cell Biol. 197:131-140(2012) [PubMed] [Europe PMC] [Abstract]
- "Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation."Mol. Cell 49:719-729(2013) [PubMed] [Europe PMC] [Abstract]