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Integrin Alpha 2B (ITGa2B)

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CD41; CD41B; ITG-A2B; GTA; GP2B; GPIIb; HPA3; Platelet Glycoprotein IIb Of IIb/IIIa Complex; Antigen CD41

Integrin Alpha 2B (ITGa2B)
CCC B029
HGNC 6138
MGI 96601
PubMed 22952660
UniProt P08514
Wiki ITGA2B

ITGA2B encodes integrin alpha chain 2b. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.The ITGA2B gene encodes platelet glycoprotein IIb, the alpha subunit of the platelet membrane adhesive protein receptor complex GPIIb/IIIa. The beta subunit, GPIIIa, is encoded by the ITGB3 gene. The GPIIb/IIIa complex belongs to the integrin class of cell adhesion molecule receptors that share a common heterodimeric structure with alpha and beta subunits.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB029Hu01 Recombinant Integrin Alpha 2B (ITGa2B) Positive Control; Immunogen; SDS-PAGE; WB.
RPB029Hu02 Recombinant Integrin Alpha 2B (ITGa2B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB029Hu01 Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
MAB029Hu21 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
MAB029Hu22 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
MAB029Hu23 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
MAB029Hu24 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
MAB029Hu25 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
MAB029Hu27 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
MAB029Hu29 Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
PAB029Hu02 Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) WB; IHC; ICC; IP.
Assay Kits SEB029Hu ELISA Kit for Integrin Alpha 2B (ITGa2B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Integrin Alpha 2B (ITGa2B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Integrin Alpha 2B (ITGa2B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Integrin Alpha 2B (ITGa2B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Integrin Alpha 2B (ITGa2B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Integrin Alpha 2B (ITGa2B) ELISA Kit Customized Service Offer
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  42. ErratumNat. Genet. 23:373-373(1999)
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  47. "Two novel mutations in the alpha IIb calcium-binding domains identify hydrophobic regions essential for alpha IIbbeta 3 biogenesis."Blood 101:2268-2276(2003) [PubMed] [Europe PMC] [Abstract]
  48. "A naturally occurring Tyr143His alpha IIb mutation abolishes alpha IIb beta 3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects."Blood 101:3485-3491(2003) [PubMed] [Europe PMC] [Abstract]
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