Alpha-Lactalbumin (aLA)

[Edit]

LALBA; LYZL7; Lactose Synthase B Protein; Lysozyme Like Protein 7

Alpha-Lactalbumin (aLA)

Alpha-lactalbumin is an important whey protein in cow's milk (~1 g/l), and is also present in the milk of many other mammalian species. In primates, alpha-lactalbumin expression is upregulated in response to the hormone prolactin and increases the production of lactose. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta-1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transferring galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB018Hu01 Recombinant Alpha-Lactalbumin (aLA) Positive Control; Immunogen; SDS-PAGE; WB.
NPB018Hu01 Native Alpha-Lactalbumin (aLA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB018Hu01 Polyclonal Antibody to Alpha-Lactalbumin (aLA) WB; IHC; ICC; IP.
MAB018Hu22 Monoclonal Antibody to Alpha-Lactalbumin (aLA) WB; IHC; ICC; IP.
MAB018Hu21 Monoclonal Antibody to Alpha-Lactalbumin (aLA) WB; IHC; ICC; IP.
Assay Kits SEB018Hu ELISA Kit for Alpha-Lactalbumin (aLA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB018Mu01 Recombinant Alpha-Lactalbumin (aLA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB018Mu01 Polyclonal Antibody to Alpha-Lactalbumin (aLA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-Lactalbumin (aLA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-Lactalbumin (aLA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB018Ra01 Recombinant Alpha-Lactalbumin (aLA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB018Ra01 Polyclonal Antibody to Alpha-Lactalbumin (aLA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Alpha-Lactalbumin (aLA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Alpha-Lactalbumin (aLA) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB018Bo01 Recombinant Alpha-Lactalbumin (aLA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB018Bo01 Polyclonal Antibody to Alpha-Lactalbumin (aLA) WB; IHC; ICC; IP.
MAB018Bo21 Monoclonal Antibody to Alpha-Lactalbumin (aLA) WB; IHC; ICC; IP.
Assay Kits SEB018Bo ELISA Kit for Alpha-Lactalbumin (aLA) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene."Nucleic Acids Res. 10:3503-3515(1982) [PubMed] [Europe PMC] [Abstract]
  2. "Organization and sequence of the human alpha-lactalbumin gene."Biochem. J. 242:735-742(1987) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The complete amino-acid sequence of human alpha-lactalbumin."Eur. J. Biochem. 27:65-86(1972) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of a new molecular form of human alpha-lactalbumin."J. Dairy Res. 59:425-429(1992) [PubMed] [Europe PMC] [Abstract]
  6. "An unusual glycosylation site in alpha-lactalbumin from human milk."Protein Sci. 4 Suppl. 1:119-119(1995)
  7. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of human alpha-lactalbumin at 1.7-A resolution."J. Mol. Biol. 221:571-581(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Alpha-lactalbumin possesses a distinct zinc binding site."J. Biol. Chem. 268:19292-19298(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin."Biochemistry 37:4767-4772(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Crystallographic evaluation of internal motion of human alpha-lactalbumin refined by full-matrix least-squares method."J. Mol. Biol. 287:347-358(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Detection of a single nucleotide polymorphism in the human alpha-lactalbumin gene: implications for human milk proteins."J. Nutr. Biochem. 16:272-278(2005) [PubMed] [Europe PMC] [Abstract]