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P-Selectin Glycoprotein Ligand 1 (PSGL1)

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CD162; SELPLG; CLA; Selectin P Ligand

P-Selectin Glycoprotein Ligand 1 (PSGL1)
CCC A985
HGNC 10722
MGI 106689
PubMed 19967153
RGD 1307971
UniProt Q14242
Wiki CD162

SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.

P-selectin glycoprotein ligand-1 is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet). It is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). PSGL-1 can bind to all three members of the family but binds best (with the highest affinity) to P-selectin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPA985Hu61 Eukaryotic P-Selectin Glycoprotein Ligand 1 (PSGL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to P-Selectin Glycoprotein Ligand 1 (PSGL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to P-Selectin Glycoprotein Ligand 1 (PSGL1) Polyclonal Antibody Customized Service Offer
Assay Kits SEA985Hu ELISA Kit for P-Selectin Glycoprotein Ligand 1 (PSGL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA985Mu01 Recombinant P-Selectin Glycoprotein Ligand 1 (PSGL1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA985Mu02 Recombinant P-Selectin Glycoprotein Ligand 1 (PSGL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA985Mu01 Polyclonal Antibody to P-Selectin Glycoprotein Ligand 1 (PSGL1) WB; IHC; ICC; IP.
PAA985Mu02 Polyclonal Antibody to P-Selectin Glycoprotein Ligand 1 (PSGL1) WB; IHC; ICC; IP.
Assay Kits SEA985Mu ELISA Kit for P-Selectin Glycoprotein Ligand 1 (PSGL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA985Ra01 Recombinant P-Selectin Glycoprotein Ligand 1 (PSGL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA985Ra01 Polyclonal Antibody to P-Selectin Glycoprotein Ligand 1 (PSGL1) WB; IHC; ICC; IP.
MAA985Ra21 Monoclonal Antibody to P-Selectin Glycoprotein Ligand 1 (PSGL1) WB; IHC; ICC; IP.
Assay Kits SEA985Ra ELISA Kit for P-Selectin Glycoprotein Ligand 1 (PSGL1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant P-Selectin Glycoprotein Ligand 1 (PSGL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to P-Selectin Glycoprotein Ligand 1 (PSGL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to P-Selectin Glycoprotein Ligand 1 (PSGL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for P-Selectin Glycoprotein Ligand 1 (PSGL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for P-Selectin Glycoprotein Ligand 1 (PSGL1) ELISA Kit Customized Service Offer
  1. "Genomic organization and chromosomal localization of the gene encoding human P-selectin glycoprotein ligand."J. Biol. Chem. 270:16470-16475(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Expression cloning of a functional glycoprotein ligand for P-selectin."Cell 75:1179-1186(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine."J. Biol. Chem. 269:23318-23327(1994) [PubMed] [Europe PMC] [Abstract]
  7. "A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding."Cell 83:323-331(1995) [PubMed] [Europe PMC] [Abstract]
  8. "PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus."Cell 83:333-343(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin."J. Biol. Chem. 270:22677-22680(1995) [PubMed] [Europe PMC] [Abstract]
  10. "Structures of the O-glycans on P-selectin glycoprotein ligand-1 from HL-60 cells."J. Biol. Chem. 271:18732-18742(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin."J. Biol. Chem. 275:7839-7853(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Tyrosine sulfation enhances but is not required for PSGL-1 rolling adhesion on P-selectin."Biophys. J. 81:2001-2009(2001) [PubMed] [Europe PMC] [Abstract]
  13. "ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1."Immunity 17:401-412(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51."J. Biol. Chem. 278:37-47(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin."J. Biol. Chem. 278:26391-26400(2003) [PubMed] [Europe PMC] [Abstract]
  16. "SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1."Eur. J. Immunol. 38:550-564(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1."Cell 103:467-479(2000) [PubMed] [Europe PMC] [Abstract]
  19. ErratumCell 105:971-971(2001)