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ATP Binding Cassette Transporter G2 (ABCG2)

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CDw338; CD338; ABC-G2; MRX; BCRP1; ABC15; ABCP; BCRP; BMDP; MXR; MXR1; Mitoxantrone resistance-associated protein; Breast Cancer Resistance Protein 1; Urate exporter

ATP Binding Cassette Transporter G2 (ABCG2)
CCC A960
HGNC 74
MGI 1347061
PubMed 11801536
RGD 631345
UniProt Q9UNQ0
Wiki ABCG2

ATP-binding cassette, sub-family G (WHITE), member 2 is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA960Hu01 Recombinant ATP Binding Cassette Transporter G2 (ABCG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA960Hu01 Polyclonal Antibody to ATP Binding Cassette Transporter G2 (ABCG2) WB; IHC; ICC; IP.
MAA960Hu22 Monoclonal Antibody to ATP Binding Cassette Transporter G2 (ABCG2) WB; IHC; ICC; IP.
Assay Kits SEA960Hu ELISA Kit for ATP Binding Cassette Transporter G2 (ABCG2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA960Mu01 Recombinant ATP Binding Cassette Transporter G2 (ABCG2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA960Mu02 Recombinant ATP Binding Cassette Transporter G2 (ABCG2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA960Mu01 Polyclonal Antibody to ATP Binding Cassette Transporter G2 (ABCG2) WB; IHC; ICC; IP.
PAA960Mu02 Polyclonal Antibody to ATP Binding Cassette Transporter G2 (ABCG2) WB; IHC; ICC; IP.
Assay Kits SEA960Mu ELISA Kit for ATP Binding Cassette Transporter G2 (ABCG2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP Binding Cassette Transporter G2 (ABCG2) Recombinant Protein Customized Service Offer
Antibodies PAA960Ra01 Polyclonal Antibody to ATP Binding Cassette Transporter G2 (ABCG2) WB; IHC; ICC; IP.
Assay Kits SEA960Ra ELISA Kit for ATP Binding Cassette Transporter G2 (ABCG2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance."Cancer Res. 58:5337-5339(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A multidrug resistance transporter from human MCF-7 breast cancer cells."Proc. Natl. Acad. Sci. U.S.A. 95:15665-15670(1998) [PubMed] [Europe PMC] [Abstract]
  3. ErratumProc. Natl. Acad. Sci. U.S.A. 96:2569-2569(1999)
  4. "Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure."Cancer Res. 61:2827-2832(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype."Nat. Med. 7:1028-1034(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The expression and functional characterization of ABCG2 in brain endothelial cells and vessels."FASEB J. 17:2085-2087(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes."Cancer Res. 59:8-13(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Role of ABCG1 and other ABCG family members in lipid metabolism."J. Lipid Res. 42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2."J. Biol. Chem. 279:19781-19789(2004) [PubMed] [Europe PMC] [Abstract]
  13. "N-linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membrane."Biochemistry 44:5420-5429(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition."Biochim. Biophys. Acta 1668:53-63(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2."J. Cell Sci. 118:1417-1426(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein."J. Biol. Chem. 282:27841-27846(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study."Lancet 372:1953-1961(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout."Proc. Natl. Acad. Sci. U.S.A. 106:10338-10342(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population." Sci. Transl. Med. 1:5ra11-5ra11(2009) [PubMed] [Europe PMC] [Abstract]
  20. "ABCG2 transports and transfers heme to albumin through its large extracellular loop."J. Biol. Chem. 285:33123-33133(2010) [PubMed] [Europe PMC] [Abstract]
  21. "ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans."Nucleosides Nucleotides Nucleic Acids 30:1091-1097(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Human ABCG2: structure, function, and its role in multidrug resistance."Int. J. Biochem. Mol. Biol. 3:1-27(2012) [PubMed] [Europe PMC] [Abstract]
  23. "ABCG2 null alleles define the Jr(a-) blood group phenotype."Nat. Genet. 44:131-132(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior."Nat. Genet. 44:174-177(2012) [PubMed] [Europe PMC] [Abstract]
  25. "Mitochondrial localization of ABC transporter ABCG2 and its function in 5-aminolevulinic acid-mediated protoporphyrin IX accumulation."PLoS ONE 7:E50082-E50082(2012) [PubMed] [Europe PMC] [Abstract]
  26. "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8."J. Hum. Genet. 47:285-310(2002) [PubMed] [Europe PMC] [Abstract]
  27. "Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan."Drug Metab. Pharmacokinet. 18:212-217(2003) [PubMed] [Europe PMC] [Abstract]
  28. "Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine."Pharmacogenetics 13:19-28(2003) [PubMed] [Europe PMC] [Abstract]
  29. "Single nucleotide polymorphisms modify the transporter activity of ABCG2."Cancer Chemother. Pharmacol. 56:161-172(2005) [PubMed] [Europe PMC] [Abstract]
  30. "Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population."Drug Metab. Pharmacokinet. 21:109-121(2006) [PubMed] [Europe PMC] [Abstract]